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Results describe the expression pattern of Xenopus islet-1 (Xisl-1) in the context of cardiovascular development.
Knock-down of Xisl-1 by specific morpholino leads to severe developmental defects, including eye and heart failure.
Mechanistic analyses integrate this unrecognized anti-atrial function of ISL1 with known and newly identified atrial inducers. In this revised view, ISL1 is antagonized by retinoic acid signaling via a novel player, MEIS2 (show MEIS2 Proteins).
In the present study, the protein inhibitor of activated STAT (show STAT1 Proteins) Y (PIASy (show PIAS4 Proteins)) was identified as a novel Isl1-interacting protein. Furthermore, PIASy (show PIAS4 Proteins) and Isl1 upregulate insulin (show INS Proteins) gene expression and insulin (show INS Proteins) secretion in a dose-dependent manner by activating the insulin (show INS Proteins) promoter.
Data show that Islet-1 (ISL1) activated the expression of cyclin B1 (CCNB1 (show CCNB1 Proteins)), cyclin B2 (CCNB2 (show CCNB2 Proteins)) and c-myc (c-MYC (show MYC Proteins)) genes by binding to the conserved binding sites on their promoters or enhancers.
results identify Isl1 as a crucial transcription factor that plays essential roles in the gene regulatory program directing development of multiple arcuate neuronal subpopulations.
ISL-1 is widely expressed in Olfactory neuroblastoma (show ARHGEF16 Proteins) tumors with neuroendocrine differentiation and therefore of limited value in their differential diagnosis
Data indicate that cells cultured on cardiac muscle laminin (LN)-based substrata in combination with stimulation of the canonical Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway showed increased gene expression of ISL1, OCT4 (show POU5F1 Proteins), KDR (show KDR Proteins) and NKX2.5 (show NKX2-5 Proteins).
In bladder exstrophy there is a clear correlation with the a mutation of the chromosome 5 ISL1 (5q11.1) gene.
SSBP3 (show SSBP3 Proteins) Interacts With Islet-1 and Ldb1 (show LDB1 Proteins) to Impact Pancreatic beta-Cell Target Genes
Concurrent ISL1/HOXA9 (show HOXA9 Proteins) methylation in HG-NMIBC reliably predicted tumour recurrence and progression within one year (Positive Predictive Value 91.7%), and was associated with disease-specific mortality
Isl1 overexpression in embryonic stem cells results in normal electrophysiologically functioning cells.
ISL1 plays a central role in proper patterning of stem cell-derived enamel in the incisor and indicate that this factor is an important upstream regulator of signaling pathways during tooth development and renewal.
Both ISL1-LHX3 and ISL1-LHX4 bound to the Slit2 enhancer.
results support a model in which Gata6 (show GATA6 Proteins) contributes to repression of Isl1 expression in the anterior of nascent hindlimb buds.
The results demonstrated that Islet1 upregulated expression of general control of amino acid biosynthesis protein 5 (show CAPS Proteins) (Gcn5 (show KAT2A Proteins)) and enhanced the binding of Gcn5 (show KAT2A Proteins) to the promoters of GATA binding protein 4 (GATA4 (show GATA4 Proteins)) and NK2 homeobox 5 (Nkx2.5 (show NKX2-5 Proteins)). In addition, Islet-1 downregulated DNA methyltransferase (show DNMT1 Proteins) (DNMT)1 (show DNMT1 Proteins) expression and reduced its binding to the GATA4 (show GATA4 Proteins) promoter.
Isl1beta is a key additional transcriptional factor for advancing the generation of insulin (show INS Proteins)-producing cells in the liver in combination with PDA (Pdx1 (show PDX1 Proteins), Neurod1 (show NEUROD1 Proteins), and Mafa (show MAFA Proteins)).
Overexpression of Islet1 affects the development and function of the cerebello-vestibular system, resulting in hyperactivity.
Results show that specific genomic loci associated with Islet-1 (Isl1) , LIM-homeobox 3 (Lhx3 (show LHX3 Proteins)), and LMO4 (show LMO4 Proteins) genes recruit the Isl1-Lhx3 (show LHX3 Proteins) complex to activate the transcription of Isl1, Lhx3 (show LHX3 Proteins), and Lmo4 (show LMO4 Proteins).
these results uncover a novel role for VEGF (show VEGFA Proteins) in controlling proper allocation of Isl1(+) cardiac progenitors to their respective descending lineages
CITED2 (show CITED2 Proteins) and ISL1 proteins interact physically and cooperate to promote embryonic stem cell differentiation toward cardiomyocytes.
Together, the authors show the antagonistic regulation of the alpha-enhancer activity by Pax6 (show PAX6 Proteins) and the LIM protein (show PDLIM1 Proteins) complex is necessary for the establishment of an inner retinal circuitry, which controls visual adaptation.
Nkx2-5 and nkx2.7 genes restrict proliferation of heart field progenitors in the outflow tract, delimit the number of progenitors at the venous pole and pattern the sinoatrial node acting through Isl1 repression.
Arx contributes to patterning in the prethalamic region, while Isl1 is required for differentiation of prethalamic dopaminergic neurons.
Ajuba plays a central role in regulating the second heart field during heart development by linking retinoic acid signaling to the function of Isl1, a key transcription factor in cardiac progenitor cells.
Isl1 is required for the selective outgrowth of the peripheral axons of Rohon-beard neurons.
prdm1a (show PRDM1 Proteins) Regulates sox10 (show SOX10 Proteins) and islet1 in the development of neural crest and Rohon-Beard sensory neurons.
By direct comparison of the upstream flanking regions of the zebrafish and human isl1 genes, we identified another highly conserved noncoding element.
primary motoneuron subtypes are likely to be specified by factors that act in parallel to or upstream of islet1 and islet2
Nkx6 proteins regulate MiP motorneuron development at least in part by maintaining the islet1 expression that is required both to promote the MiP subtype and to suppress interneuron development.
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.
, ISL1 transcription factor, LIM/homeodomain, (islet-1)
, domesticus (clone 1.7 kB) islet-1
, insulin gene enhancer protein ISL-1
, ISL1 transcription factor, LIM/homeodomain
, ISL1 transcription factor LIM/homeodomain (islet-1)
, ISL1 transcription factor, LIM/homeodomain 1
, isl-1 homeobox
, Insulin gene enhancer protein ISL-1
, Islet 1
, Lim-homeodomain protein Islet1
, insulin related protein
, insulin gene enhancer protein isl-1