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Results describe the expression pattern of Xenopus islet-1 (Xisl-1) in the context of cardiovascular development.
Knock-down of Xisl-1 by specific morpholino leads to severe developmental defects, including eye and heart failure.
Data show that Islet-1 (ISL1) activated the expression of cyclin B1 (CCNB1 (show CCNB1 Proteins)), cyclin B2 (CCNB2 (show CCNB2 Proteins)) and c-myc (c-MYC (show MYC Proteins)) genes by binding to the conserved binding sites on their promoters or enhancers.
results identify Isl1 as a crucial transcription factor that plays essential roles in the gene regulatory program directing development of multiple arcuate neuronal subpopulations.
ISL-1 is widely expressed in Olfactory neuroblastoma (show ARHGEF16 Proteins) tumors with neuroendocrine differentiation and therefore of limited value in their differential diagnosis
Data indicate that cells cultured on cardiac muscle laminin (LN)-based substrata in combination with stimulation of the canonical Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway showed increased gene expression of ISL1, OCT4 (show POU5F1 Proteins), KDR (show KDR Proteins) and NKX2.5 (show NKX2-5 Proteins).
In bladder exstrophy there is a clear correlation with the a mutation of the chromosome 5 ISL1 (5q11.1) gene.
SSBP3 (show SSBP3 Proteins) Interacts With Islet-1 and Ldb1 (show LDB1 Proteins) to Impact Pancreatic beta-Cell Target Genes
Concurrent ISL1/HOXA9 (show HOXA9 Proteins) methylation in HG-NMIBC reliably predicted tumour recurrence and progression within one year (Positive Predictive Value 91.7%), and was associated with disease-specific mortality
Isl1 overexpression in embryonic stem cells results in normal electrophysiologically functioning cells.
The present study identified the first genome-wide significant locus for classic bladder exstrophy at chromosomal region 5q11.1, and provides strong evidence for the hypothesis that ISL1 is the responsible candidate gene in this region.
Suggest that ISL-1 may be a useful prognostic biomarker and may represent a novel therapeutic target for gastric adenocarcinoma.
Results show that specific genomic loci associated with Islet-1 (Isl1) , LIM-homeobox 3 (Lhx3 (show LHX3 Proteins)), and LMO4 (show LMO4 Proteins) genes recruit the Isl1-Lhx3 (show LHX3 Proteins) complex to activate the transcription of Isl1, Lhx3 (show LHX3 Proteins), and Lmo4 (show LMO4 Proteins).
these results uncover a novel role for VEGF (show VEGFA Proteins) in controlling proper allocation of Isl1(+) cardiac progenitors to their respective descending lineages
CITED2 (show CITED2 Proteins) and ISL1 proteins interact physically and cooperate to promote embryonic stem cell differentiation toward cardiomyocytes.
Together, the authors show the antagonistic regulation of the alpha-enhancer activity by Pax6 (show PAX6 Proteins) and the LIM protein (show PDLIM1 Proteins) complex is necessary for the establishment of an inner retinal circuitry, which controls visual adaptation.
PDX1 (show PDX1 Proteins) and ISL1 regulation of insulin (show INS Proteins) gene expression in pancreatic beta cells, was investigated.
Expression of motor neuron effector genes is maintained by transient enhancers bound by Isl1/Lhx3 (show LHX3 Proteins) in nascent motor neurons and Isl1/Onecut1 (show ONECUT1 Proteins) in maturing hypaxial motor neurons.
These data reveal functional roles for an ISLET1-dependent network integrating beta-catenin (show CTNNB1 Proteins)/SHH (show SHH Proteins) signals in mesenchymal cell survival and outgrowth of the mandible during development.
ISL1 and JMJD3 partner to alter the cardiac epigenome, instructing gene expression changes that drive cardiac differentiation.
Pax2 (show PAX2 Proteins)-regulated ISL1 overexpression increases the embryonic ISL1(+) domain and induces accelerated nerve fiber extension and branching in E12.5 embryos.
Arx contributes to patterning in the prethalamic region, while Isl1 is required for differentiation of prethalamic dopaminergic neurons.
Ajuba plays a central role in regulating the second heart field during heart development by linking retinoic acid signaling to the function of Isl1, a key transcription factor in cardiac progenitor cells.
Isl1 is required for the selective outgrowth of the peripheral axons of Rohon-beard neurons.
prdm1a (show PRDM1 Proteins) Regulates sox10 (show SOX10 Proteins) and islet1 in the development of neural crest and Rohon-Beard sensory neurons.
By direct comparison of the upstream flanking regions of the zebrafish and human isl1 genes, we identified another highly conserved noncoding element.
primary motoneuron subtypes are likely to be specified by factors that act in parallel to or upstream of islet1 and islet2
Nkx6 proteins regulate MiP motorneuron development at least in part by maintaining the islet1 expression that is required both to promote the MiP subtype and to suppress interneuron development.
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.
, ISL1 transcription factor, LIM/homeodomain, (islet-1)
, domesticus (clone 1.7 kB) islet-1
, insulin gene enhancer protein ISL-1
, ISL1 transcription factor, LIM/homeodomain
, ISL1 transcription factor LIM/homeodomain (islet-1)
, ISL1 transcription factor, LIM/homeodomain 1
, isl-1 homeobox
, Insulin gene enhancer protein ISL-1
, Islet 1
, Lim-homeodomain protein Islet1
, insulin related protein
, insulin gene enhancer protein isl-1