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High plasma kisspeptin-1 is associated with premature thelarche.
Data suggest that subjects with anorexia nervosa display broad spectrum of physical activity (2479-26,047 steps/day) which shows a negative correlation with plasma kisspeptin levels and a positive association with plasma ghrelin (show GHRL Proteins) levels.
Kisspeptin-10 may contribute to accelerate the progression and instability of atheromatous plaques, leading to plaque rupture. The GPR54 antagonist may be useful for prevention and treatment of atherosclerosis.
we conclude that KISS-1 can inhibit the proliferation of osteosarcoma in vitro by accelerating the processes of apoptosis and autophagy.
These findings suggest that infundibular kisspeptin neurons are sensitive to circulating sex steroid hormones throughout life and that the sex reversal observed in MTF transsexuals might reflect, at least partially, an atypical brain sexual differentiation.
Patients with ovarian epithelial cancer and low KISS1 mRNA expression had shorter survival time than those with high expression (P = 0.001).Preoperative KISS1 mRNA was a potential prognostic biomarker for EOC, and high preoperative KISS1 expression indicated a favorable prognosis.
Lower expression of KiSS1 was observed in metastatic Breast Cancer.
KAI1 (show CD82 Proteins) and KISS1 are implicated in the pathogenesis and maintenance of endometriosis.
In human cumulus GCs, kiss1r mRNA levels were positively correlated with age but not with BMI. There was no expression of kiss1 mRNA in either cumulus or mural GCs
Overexpression of KiSS-1 suppressed the invasiveness of CRC (show CALR Proteins) cells, and the gene exerted its function by reducing the expression of MMP-9 (show MMP9 Proteins) via blocking of tge (show TGM3 Proteins) PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/NF-kappaB (show NFKB1 Proteins) pathway.
The findings are consistent with the idea that, during metabolic deficiency, AgRP (show AGRP Proteins) signaling contributes to infertility by inhibiting Kiss1 neurons.
Study used Cre-lox (show LOX Proteins) technology to selectively ablate tyrosine hydroxylase (TH (show TH Proteins)) from Kiss1 cells. Surprisingly, despite a practically complete knock-out of TH from Kiss1 cells, study found that all aspects of puberty, reproductive hormone secretion, and fertility were normal in Kiss THKOs. This suggests that dopamine synthesized in Kiss1 cells is not required for normal puberty and reproduction.
Kisspeptin governs both mate preference and sexual motivation in female mice, indicating that sexual behavior and ovulation are coordinated by the same neuropeptide.
Study found unaltered hypothalamic metabolic gene expression in Kiss1 receptor knockout mice despite obesity and reduced energy expenditure.
POMC (show POMC Proteins) and AgRP (show AGRP Proteins) neurons receive direct steroid- and frequency-dependent glutamatergic synaptic input from Kiss1(ARC (show NOL3 Proteins)) neurons in male mice
mice carrying Stat5a (show STAT5A Proteins)/b inactivation specifically in kisspeptin cells were generated. These mutants exhibited an early onset of estrous cyclicity, indicating that STAT5 (show STAT5A Proteins) transcription factors exert an inhibitory effect on the timing of puberty.
Nesfatin-1 increased Kiss1R expression in hypothalamic cells.
steroidal environment and energy state negatively regulate kisspeptin (Kiss1), neurokinin B (Tac2), and dynorphin (Pdyn (show PDYN Proteins)) gene expression.
loss of PGR (show PGR Proteins) impairs kisspeptin secretory machinery and therefore that PGR (show PGR Proteins) plays a critical role in regulating kisspeptin secretion.
kiss1 and ghrh3 double mutants retain reproductive capacity
results reveal the pattern of kisspeptin neurones and their connections with GnRH3 neurones in the brain, suggesting distinct mechanisms for Kiss1 and Kiss2 in regulating reproductive events in zebrafish.
These findings implicate that Kiss1 could modulate fear responses mediated by 5-HT1A and 5-HT2 receptors
These findings suggest that the autocrine-regulated habenular Kiss1 neurons indirectly regulate the serotonergic system in the raphe nuclei through the habenula-interpeduncular nucleus in the zebrafish.
Dada (show ADA Proteins) show that kiss1-expressing neurons are only located in the habenular nucleus, while kiss2-expressing neurons are found in the dorsal and ventral hypothalamus.
The zebrafish kiss1 was expressed in brain, intestine, adipose tissue and testis.
Kiss1/Kiss1r system may participate in puberty initiation in fish as well.
Kisspeptin neuronal system plays an essential role as the gatekeeper of reproduction via stimulating GnRH secretion.(review)
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues.
, malignant melanoma metastasis-suppressor
, metastasis-suppressor KiSS-1
, G protein-coupled receptor 54
, G-protein coupled receptor 54
, G-protein coupled receptor OT7T175
, kiSS-1 receptor
, kisspeptins receptor
, metastin receptor
, orphan G protein-coupled receptor 54
, kisspeptin 1
, Kiss1 metastasis-suppressor
, Kiss1 variant E1a-E2b-E3
, Kiss1 variant E1b-E2a-E3
, Kiss1 variant E1b-E2b-E3
, MLL septin-like fusion