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|Antigen||Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This BRE antibody is conjugated to Alexa Fluor 350 Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
Product Details anti-BRE AntibodyTarget Details BRE Application Details Handling Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human BRCC45|
|Plasmids, Primers & others|
Target Details BREProduct Details anti-BRE Antibody Application Details Handling Images back to top
|Alternative Name||Brcc45 (BRE Antibody Abstract)|
BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs. Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36. This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage. BRCC45 has also been suggested to function as a death receptor associated anti apoptotic protein by inhibiting the BID induced activation of the mitochondrial apoptotic pathway. Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, suggesting that BRCC45 may promote tumorigenesis when overexpressed. At least three isoforms of BRCC45 are known to exist.
Synonyms: Brain and reproductive organ expressed TNFRSF1A modulator, BRCA1/BRCA2 containing complex subunit 4, BRCA1/BRCA2 containing complex subunit 45, BRCC4, BRCC45, BRE_HUMAN.
|Pathways||Positive Regulation of Response to DNA Damage Stimulus|
Application DetailsProduct Details anti-BRE Antibody Target Details BRE Handling Images back to top
|Application Notes||IF(IHC-P) 1:50-200|
|Restrictions||For Research Use only|
HandlingProduct Details anti-BRE Antibody Target Details BRE Application Details Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at 4°C|
|Expiry Date||12 months|