anti-Rat (Meriones) BRE antibody for Western Blotting

Recommended BRE Antibody (supplied by: Log in to see )

Antigen
Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) Antibodies
  • brcc4
  • brcc45
  • BRE
  • LOC100231620
  • BRCC4
  • BRCC45
  • 6030405P19Rik
  • AI429776
  • B830038C02Rik
  • im:7141046
  • zgc:110368
  • BRISC and BRCA1 A complex member 2
  • brain and reproductive organ-expressed (TNFRSF1A modulator)
  • BRISC and BRCA1 A complex member 2 L homeolog
  • babam2
  • BABAM2
  • Babam2
  • BRE
  • babam2.L
Reactivity
Human, Mouse (Murine), Rat (Meriones)
70
52
43
2
2
2
2
2
2
1
1
1
1
1
Host
Rabbit
67
3
Clonality
Polyclonal
Conjugate
This BRE antibody is un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
55
26
26
22
20
13
13
5
3
2
1
1
1
Options
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Available images

Catalog No. ABIN2801968
$ 385.00
Plus shipping costs $45.00

General

Antigen Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) Antibodies
Reactivity Human, Mouse (Murine), Rat (Meriones)
(70), (52), (43), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Host Rabbit
(67), (3)
Clonality
Polyclonal
Conjugate This BRE antibody is un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Western Blotting (WB)
(55), (26), (26), (22), (20), (13), (13), (5), (3), (2), (1), (1), (1)
Pubmed 4 references available
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Product Details anti-BRE Antibody

Target Details BRE Application Details Handling References for anti-BRE antibody (ABIN2801968) Images
Isotype IgG
Plasmids, Primers & others

Target Details BRE

Product Details anti-BRE Antibody Application Details Handling References for anti-BRE antibody (ABIN2801968) Images back to top
Antigen
Alternative Name BRE (BRE Antibody Abstract)
Background Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti- apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A, however these effects may be indirect.
Synonyms: BRCA1-A complex subunit BRE, BRCA1/BRCA2-containing complex subunit 45, Brain and reproductive organ-expressed protein, BRE, BRCC45
Molecular Weight 43552 Da
Gene ID 9577
UniProt Q9NXR7
Pathways Positive Regulation of Response to DNA Damage Stimulus

Application Details

Product Details anti-BRE Antibody Target Details BRE Handling References for anti-BRE antibody (ABIN2801968) Images back to top
Application Notes WB - 1:1000
Restrictions For Research Use only

Handling

Product Details anti-BRE Antibody Target Details BRE Application Details References for anti-BRE antibody (ABIN2801968) Images back to top
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

References for anti-BRE antibody (ABIN2801968)

Product Details anti-BRE Antibody Target Details BRE Application Details Handling Images back to top
Product cited in:

Dong, Hakimi, Chen, Kumaraswamy, Cooch, Godwin, Shiekhattar: "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair." in: Molecular cell, Vol. 12, Issue 5, pp. 1087-99, 2003

Ching, Li, Li, Chan, Chan, Lim, Pang, Chui: "Expression of human BRE in multiple isoforms." in: Biochemical and biophysical research communications, Vol. 288, Issue 3, pp. 535-45, 2001

Li, Yoo, Becker, Ali-Osman, Chan: "Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid." in: Biochemical and biophysical research communications, Vol. 206, Issue 2, pp. 764-74, 1995

Background publications

Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003

Images

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Supplier Images
Western Blotting (WB) image for anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) antibody (ABIN2801968) anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) antibody