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CD70 (show CD70 Proteins) reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies.
CD27-dependent CD8 (show CD8A Proteins)(+) T cell priming and differentiation are shaped by the efficiency of NK responses to virus infection.
HSCs appear to maintain expression of CD27 after hematopoietic injury when Kit expression is downregulated.
Mature CD27low NK cells promote allograft survival under costimulatory blockade conditions by regulating alloreactive memory CD8+ T-cell responses in T-bet dependent manner.
identify an IL-17 (show IL17A Proteins)-dependent lymphoid/myeloid cross-talk involving CD27(-) gammadelta T cells and small peritoneal macrophages that promotes ovarian tumor cell growth and thus counteracts cancer immunosurveillance
memory CD8 (show CD8A Proteins) T cells, generated through priming with CD27 agonists, proliferated more extensively than did 4-1BB (show TNFRSF9 Proteins)-generated memory cells, but these cells failed to persist.
the central role played by CD27/70 during secondary CD8 (show CD8A Proteins)(+) T-cell activation to a peptide Ag, and identify sCD70 as an immunotherapeutic adjuvant for antitumor immunity.
under conditions of constitutive CD70 (show CD70 Proteins) expression reflecting chronic immune activation, the CD27/CD70 (show CD70 Proteins) system inhibits OC differentiation and favors DC differentiation
mTECs and DCs form dedicated niches in the thymic medulla, in which CD27-CD70 (show CD70 Proteins) co-stimulation rescues developing Treg cells from apoptosis, subsequent to Foxp3 (show FOXP3 Proteins) induction by TCR and CD28 (show CD28 Proteins) signals.
The CD27 and CD70 (show CD70 Proteins) costimulatory pathway inhibits effector function of T helper 17 cells and attenuates associated autoimmunity.
Crystal structure of CD27 in complex with a neutralizing noncompeting antibody has been reported.
High CD27 expression is associated with B-cell Lymphoma.
activated CD70 (show CD70 Proteins)-expressing lymphocytes may trigger CD27 on AML (show RUNX1 Proteins) blasts or stem/progenitor cells
the CD70 (show CD70 Proteins)-CD27 pathway appears to be a crucial component of EBV-specific T cell immunity and more generally for the immune surveillance of B cells and may be a target for immunotherapy of B cell malignancies.
This study demonstrates increased level of sCD27 in patients with active vitiligo (show MITF Proteins).
This study demonstrated that Soluble CD27 in cerebrospinal fluid of patients with Clinically Isolated Syndrome was associated with multiple sclerosis diagnosis and a high relapse rate.
HCV infection increased the frequency of CD4 (show CD4 Proteins)+CXCR5 (show CXCR5 Proteins)+ T cells and decreased the frequency of CD27+IgG+ B cells. CD4 (show CD4 Proteins)+CXCR5 (show CXCR5 Proteins)+ T cells activated CD27+IgG+ B cells via the secretion of IL-21 (show IL17C Proteins).
Novel mutations in TNFRSF7/CD27 cause EBV-associated lymphoproliferative disease/hemophagocytic lymphohistiocytosis, Hodgkin lymphoma, uveitis, and recurrent infections.
NFKB1 (show NFKB1 Proteins), CD27, LAG3 (show LAG3 Proteins) and IKZF3 (show IKZF3 Proteins) are new susceptibility genes for psoriasis.
results provide the first evidence for differential expression of CD27 among CLL prognostic groups, suggest a role for ZAP-70 (show ZAP70 Proteins) dependent signaling in CD27 induction and implicate CD27 in cell-cell interactions with the lymphoid tissue microenvironment
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
tumor necrosis factor receptor superfamily, member 7
, CD27 antigen
, CD27L receptor
, CD antigen 27
, T-cell activation antigen CD27
, tumor necrosis factor receptor superfamily member 7
, T cell activation antigen S152