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Human BD-2 (show DEFB4 Antibodies) and BD-3 (show DEFB103A Antibodies) play a positive and negative regulatory role in development and proliferation of human effector CD4 (show CD4 Antibodies)+ T cells which is essential for optimal adaptive immune responses and the control of immunopathology.
The results of the present study demonstrated that the transfected with HBD3 (show DEFB103A Antibodies) gene human periodontal ligament cells and bone marrow stromal cells stably expressed HBD3 (show DEFB103A Antibodies). In addition, periodontal pathogens and cariescausing bacteria were susceptible to the antimicrobial activity of the cells.
Our results suggested that hBD3 (show DEFB103A Antibodies) is involved in the carcinogenesis and development of cervical cancer, and may serve as a biomarker or therapeutic target of this disease.
These results indicated that hBD3 (show DEFB103A Antibodies) could have therapeutic effect on systemic inflammation associated with periodontal infections via modulating macrophage activation and orientation.
Ablation of E6 by siRNA induces the tumor suppressor p53 (show TP53 Antibodies) and diminishes beta-defensin-3 (hBD3 (show DEFB103A Antibodies)) in HPV-16 positive CaSki cervical cancer cells and UM-SCC (show CYP11A1 Antibodies)-104 head and neck cancer cells.
our findings provide new insights into the molecular mechanisms how HBD2 (show DEFB4 Antibodies) and HBD3 (show DEFB103A Antibodies) interact with cells of myeloid origin and demonstrate their immuno-modulating functions during innate immune responses.
our work has revealed that hBD3 (show DEFB103A Antibodies) exhibits potent anti-inflammatory properties both in vitro and in vivo, and this effect might be correlated with inhibition of MAPK (show MAPK1 Antibodies) pathway
hBD3 (show DEFB103A Antibodies) exhibits potent anti-periodontitis properties both in vitro and in vivo, and this effect may be correlated to inhibition of the nuclear factor-kappaB pathway and macrophage polarization.
Different dynamics and pathway of disulfide bonds reduction has been demonstrated for two human defensins, HD5 (show DEFA5 Antibodies) and HBD-3 (show DEFB103A Antibodies).
In this study, the results showed genetically modified (GM) milk containing human beta-defensin-3 (HBD3 (show DEFB103A Antibodies)) was easy to be digested in simulated gastric fluid, and it did not have adverse effects on general and gastrointestinal (GI) tract health compared to conventional milk.
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 103B, which has broad spectrum antimicrobial activity and may play an important role in innate epithelial defense.
, beta-defensin 3
, defensin, beta 103
, defensin-like protein