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In this Molecular Pathways article, we briefly discuss the potential role of mucin (show SLC13A2 Proteins) synthesis in cancers, ways to improve drug delivery and disrupt mucin (show SLC13A2 Proteins) mesh to overcome chemoresistance by targeting mucin (show SLC13A2 Proteins) synthesis, and the unique opportunity to target the GCNT3 pathway for the prevention and treatment of cancers.
In HeLa cells transiently expressing C2GnT-M-GFP, knockdown of KRT1 does not affect Golgi morphology but leaves C2GnT-M outside of the Golgi, resulting in the formation of sialyl-T antigen.
low GCNT3 expression is a promising prognostic biomarker for colon cancer that could be used to identify early-stage colon cancer patients at high risk of relapse.
Golgi fragmentation is accompanied by the increased association of NMIIA with C2GnT-M and its degradation by proteasomes.
Data show that the Golgi docking of vesicular complexes (VCs (show EDC4 Proteins)) use different golgins for docking: C2GnT-M-carrying VC (C2GnT-M-VC) utilizes Giantin, whereas C1GalT1 (show C1GALT1 Proteins)-VC employs GM130 (show GOLGA2 Proteins)-GRASP65 (show GORASP1 Proteins) complex.
C2GnT2 KO mice have decreased mucosal barrier function in the digestive tract, reduced levels of circulating IgGs and fecal IgA, and increased susceptibility to experimental colitis
EGF (show EGF Proteins) suppressed C2GnT (show GCNT1 Proteins) activity in a time- and dose-dependent fashion, and also suppressed core 4 beta1,6 N-acetylglucosaminyltransferase (show GCNT1 Proteins) (C4GnT) activity
Results describe the identification of the cis (show CISH Proteins)-regulatory elements of human C2GnT-M gene.
Results report the cloning of four different bovine core 2 beta6 N-acetylglucosaminyltransferase (show GCNT2 Proteins) transcripts that are different only at 5'-untranslated regions.
This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.
glucosaminyl (N-acetyl) transferase 3, mucin type
, glucosaminyl transferase 3, mucin type
, beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3-like
, C2GnT-mucin type
, beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
, core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase
, mucus-type core 2 beta-1,6-N-acetylglucosaminyltransferase
, core 2 beta-1,6-N-acetylglucosaminyltransferase II