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Human Monoclonal TNFRSF14 Primary Antibody for CyTOF, ELISA (Capture) - ABIN4900305
Kang, Kim, Kang, Han, Nam, Kyung, Park, Kim: LIGHT up-regulated on B lymphocytes and monocytes in rheumatoid arthritis mediates cellular adhesion and metalloproteinase production by synoviocytes. in Arthritis and rheumatism 2007
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Human Monoclonal TNFRSF14 Primary Antibody for FACS - ABIN4897515
Wang, Wen, Routy, Bernard, Sekaly, Watts et al.: 4-1BBL induces TNF receptor-associated factor 1-dependent Bim modulation in human T cells and is a critical component in the costimulation-dependent rescue of functionally impaired HIV-specific CD8 T ... in Journal of immunology (Baltimore, Md. : 1950) 2007
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Human Polyclonal TNFRSF14 Primary Antibody for WB - ABIN550239
Granger, Rickert: LIGHT-HVEM signaling and the regulation of T cell-mediated immunity. in Cytokine & growth factor reviews 2003
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Human Polyclonal TNFRSF14 Primary Antibody for WB - ABIN550240
Watts: TNF/TNFR family members in costimulation of T cell responses. in Annual review of immunology 2005
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Human Polyclonal TNFRSF14 Primary Antibody for ELISA, WB - ABIN250845
Cheung, Humphreys, Potter, Norris, Shumway, Tran, Patterson, Jean-Jacques, Yoon, Spear, Murphy, Lurain, Benedict, Ware: Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway. in Proceedings of the National Academy of Sciences of the United States of America 2005
Human Polyclonal TNFRSF14 Primary Antibody for ICC, ELISA - ABIN1002432
Marsters, Ayres, Skubatch, Gray, Rothe, Ashkenazi et al.: Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB ... in The Journal of biological chemistry 1997
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Report a variant of t(14;18) negative nodal diffuse follicular lymphoma with CD23 (show FCER2 Antibodies) expression, 1p36/TNFRSF14 abnormalities, and STAT6 (show STAT6 Antibodies) mutations.
Roles of HVEM are likely to be immunosuppressive rather than activating tumor immunity and it in peripheral blood is a diagnostic marker and therapeutic target for hepatocellular carcinoma.
Low HVEM expression is associated with pancreatic and ampullary cancer.
HIV-1 produced from CD4 (show CD4 Antibodies)+ T cells bears HSV-2 receptor HVEM and can bind to and enter HSV-2-infected epithelial cells depending on HVEM-gD interaction and the presence of gB/gH/gL.
HVEM is highly expressed in ovarian serous adenocarcinoma tissues and correlated with the patient clinicopathological features.
TNFRSF14 and MAP2K1 (show MAP2K1 Antibodies) mutations are the most frequent genetic alterations found in pediatric-type follicular lymphoma (PTFL) and occur independently in most cases, suggesting that both mutations might play an important role in PTFL lymphomagenesis.
genetic landscape of Pediatric-type follicular lymphoma suggests that TNFRSF14 mutations accompanied by copy-number neutral loss of heterozygosity of the 1p36 locus in over 70% of mutated cases, as additional selection mechanism, might play a key role in the pathogenesis of this disease.
The increased immune-stimulatory capacity of lymphoma B cells with TNFRSF14 aberrations had clinical relevance, associating with higher incidence of acute GVHD in patients undergoing allogeneic hematopoietic stem cell transplantation.
These results suggest that TNFRSF14 mutations point towards a diagnosis of follicular lymphomas , and can be used in the sometimes difficult distinction between marginal zone lymphomas and follicular lymphomas
the overexpression of HVEM in ovarian cancer cells may suppress the proliferation and immune function of T cells, thus leading to the development of ovarian cancer. The current study partially explains the immune escape mechanism of ovarian cancer cells.
these data indicate that HVEM/BTLA (show BTLA Antibodies) interactions are dispensable for the formation of de novo host antidonor isotype-specific antibodies following skin transplantation
HVEM represents a critical signal for memory precursor effector cells and development of protective mucosal CD8 (show CD8A Antibodies) T cell memory
Dendritic cells require BTLA (show BTLA Antibodies) and HVEM to actively adjust tolerizing T cell responses under steady-state conditions.
we identified herpes virus entry mediator as a functional receptor that mediates SALM5 (show LRFN5 Antibodies)'s suppressive function. Our findings reveal a molecular link between the neuronal system and the immune system, and provide potential therapeutic targets for the control of CNS diseases.
results have revealed a novel role of HVEM on the regulation of IFN-I and immunopathology during Listeria infection.
our studies revealed a novel function of the HVEM cosignaling molecule and its ligands in EAU pathogenesis through the induction of Th1 (show HAND1 Antibodies)- and Th17-type T cell responses
Together, these data indicate that HVEM contributes to ocular pathogenesis independently of entry and point to an immunomodulatory role for this protein specifically on radiation-resistant cells.
results demonstrate a role for both nectin-1 (show PVRL1 Antibodies) and HVEM as receptors and suggest a further receptor which appears much less efficient.
Authors show that CD4 (show CD4 Antibodies)(+) FoxP3 (show FOXP3 Antibodies)(+) Tregs up- regulate HVEM (herpes virus entry mediator), which is a binding site for major viral glycoprotein gD, following herpes simplex virus 1 infection.
results support a model whereby BTLA (show BTLA Antibodies) on innate leukocytes is triggered by HVEM and delivers negative signals into BTLA (show BTLA Antibodies)(+) cells, thereby interfering with the protective immune response to this intestinal parasite.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of this receptor was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response.
tumor necrosis factor receptor superfamily member 14
, tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
, herpesvirus entry mediator A
, CD40-like protein
, herpes virus entry mediator A
, tumor necrosis factor receptor-like 2
, tumor necrosis factor receptor-like gene2
, herpes virus entry mediator