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anti-Rat (Rattus) ADAR Antibodies:
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Human Polyclonal ADAR Primary Antibody for IF, IHC (p) - ABIN513112
Liu, Chen, Yeh, Li, Wu, Chen, Chen, Yeh: ADAR2-mediated editing of miR-214 and miR-122 precursor and antisense RNA transcripts in liver cancers. in PLoS ONE 2014
Human Polyclonal ADAR Primary Antibody for IHC, WB - ABIN2774648
Pan, Ye, Franco, Li, Yu, Zou, Zhang, Jiao, Lin: Insulin resistance and depressive symptoms in middle-aged and elderly Chinese: findings from the Nutrition and Health of Aging Population in China Study. in Journal of affective disorders 2008
Show all 2 Pubmed References
Guinea Pig Polyclonal ADAR Primary Antibody for IHC, WB - ABIN2774647
Zhang, Liu, Jiang, Tian, Wang, Yu: Six novel mutations of the ADAR1 gene in Chinese patients with dyschromatosis symmetrica hereditaria. in Journal of dermatological science 2008
Show all 2 Pubmed References
The presence of ADA (show ADA Antibodies) activity in zebrafish brain may be important to regulate the adenosine/inosine levels in the CNS of this species
These findings suggest a role of NS4A in the interaction of BVDV with ADAR that favors virus replication.
our data shows that ADAR is essential for proper temperature adaptation, a key behavior trait that is essential for survival of flies in the wild. Moreover, our results suggest a more general role of ADAR in regulating RNA secondary structures in vivo
Deficiencies in the RNA-editing gene Adar increase sleep due to synaptic dysfunction in glutamatergic neurons.
The study demonstrates that neuronal excitability is linked to dADAR expression levels in individual neurons.
loss of Adar increases quantal size, reduces the number of quanta of neurotransmitter released and perturbs the calcium dependence of synaptic release
results demonstrate a novel role for dADAR protein in rnp (show RNPC3 Antibodies)-4f 5'-UTR (show UTS2R Antibodies) alternative intron splicing regulation which is consistent with a previously proposed model.
Data suggeset that RNA editing enzyme ADAR-mediated editing is more widespread than previously indicated and largely occurs cotranscriptionally.
the solution structure of the N-terminal dsRNA binding domain (dsRBD) of dADAR
Abolishing dADAR auto-regulation dramatically remodels the landscape of re-coding events in a site-specific manner.
network-wide temporal and spatial regulation of ADAR activity can tune the complex system of RNA-editing sites and modulate multiple ethologically relevant behavioral modalities.
Our study is the first to systematically characterize the temporal and spatial expression of full-length and truncated dADAR mRNA and protein isoforms during Drosophila embryogenesis.
Study investigated genetic, phenotypic, and interferon (show IFNA Antibodies) status of 46 patients from 37 families with neurological disease due to mutations in ADAR1. Phenotype encompassed a spectrum of Aicardi-Goutieres syndrome, isolated bilateral striatal necrosis, spastic paraparesis with normal neuroimaging, a progressive spastic dystonic motor disorder, and adult-onset psychological difficulties with intracranial calcification.
the present study performed a mutation analysis of the ADAR1 gene in two sporadic patients with typical DSH from birth, and identified two novel mutations.
ADAR1 contributes to gastric cancer development and progression via activating mTOR (show FRAP1 Antibodies)/p70S6K (show RPS6KB1 Antibodies)/S6 ribosomal protein (show RPS6 Antibodies) signaling axis.
These results extended the known functions of ADAR1 and RNA editing to the critical fine-tuning of the intracellular apoptotic signaling and also provided mechanistic explanation for ADAR1's roles in development and tumorigenesis.
These results demonstrate that ablation of RNase L (show RNASEL Antibodies) activity promotes survival of ADAR1 deficient cells even in the presence of MDA5 (show IFIH1 Antibodies) and MAVS (show MAVS Antibodies), suggesting that the RNase L (show RNASEL Antibodies) system is the primary sensor pathway for endogenous dsRNA that leads to cell death.
discuss the function of ADAR1 and its regulatory role in viral infection, and establish the relationship between ADAR1 and virus-associated sepsis (review)
The range of human disease associated with ADAR1 mutations may extend further to include other inflammatory conditions while ADAR2 (show ADARB1 Antibodies) mutations may affect psychiatric conditions.
ADAR1 is targeted by miR (show MLXIP Antibodies)-143 to regulate IL-1beta (show IL1B Antibodies)-induced HUVEC activation
The miRNAs that were found upregulated in DENV-infected cells did not control the production of infectious virus particles. On the other hand, miR (show MLXIP Antibodies)-3614-5p, which was upregulated in DENV-negative macrophages, reduced DENV infectivity and regulated ADAR1 expression, a protein that facilitates viral replication.
We detected high ADAR1 expression in half of the triple-negative breast cancer patients. In addition to DNA mutations, RNA editing can be related to neoantigens; hence, we need to explore non-synonymous mutations exclusively found using RNA sequencing data to identify clinically relevant neoantigens.
These findings shed a new light on the vital regulatory role of ADAR1(Adenosine deaminase) in hepatic immune homeostasis, chiefly its inhibitory function on the crosstalk between the NFkappaB and type-I interferons signaling cascades, restraining the development of liver inflammation and fibrosis.
ADAR1-mediated RNA editing is essential for normal erythropoiesis.
Knockout of ADAR1 dramatically inhibited injury-induced neointima formation and restored vascular smooth muscle cell remodeling.
we identified a novel ADAR1-dependent protective contribution through which hepatocytes guard against aberrant cytosolic RLR (show DHX58 Antibodies)-RNA-sensing pathway mediated inflammatory reaction in response to acute liver IR.
Thus, Adarb1 (show ADARB1 Antibodies) and Adarb2 (show ADARB2 Antibodies) have nearly exclusive expression within brain tissue, while Adar has more appreciable expression across multiple tissues.
After fear conditioning protocol, mRNA expression of ADAR1 increased in amygdala and hippocampus.
ADAR1 is an essential molecule for maintaining adult liver homeostasis and, in turn, morphological and functional integrity.
The p150 (show ABL1 Antibodies) isoform of ADAR1 uniquely regulated the MDA5 (show IFIH1 Antibodies) pathway.
transcriptional activation of Adar1 by IFN occurs in the absence of STAT1 (show STAT1 Antibodies) by a non-canonical STAT2 (show STAT2 Antibodies)-dependent pathway in mouse but not human cells.
A-to-I editing of endogenous dsRNA is the essential function of ADAR1, preventing the activation of the cytosolic dsRNA response by endogenous transcripts.
This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants.
double-stranded RNA-specific adenosine deaminase
, dsRNA adenosine deaminase
, adenosine deaminase, RNA-specific
, RNA-specific adenosine deaminase
, adenosine deaminase acting on RNA
, adenosine deaminases acting on RNA
, hypoxia, anoxia, sensitive 2
, 136 kDa double-stranded RNA-binding protein
, adenosine deaminase acting on RNA 1-A
, interferon-induced protein 4
, interferon-inducible protein 4
, RNA adenosine deaminase 1
, RNA-specific adenosine deaminase p110 form
, RNA-specific adenosine deaminase p150 form