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Human Monoclonal SIX2 Primary Antibody for RNAi, ELISA - ABIN564682
Lee, Kim, Ryu, Lee, Yang, Jeong, Kim, Lee, Kim, Hajjar, Park: Transcription coactivator Eya2 is a critical regulator of physiological hypertrophy. in Journal of molecular and cellular cardiology 2012
Show all 5 Pubmed References
Six2 is negatively correlated with good prognosis and decreases 5-FU sensitivity via suppressing E-cadherin (show CDH1 Antibodies) expression in HCC (show FAM126A Antibodies) cells.
the phenotypic spectrum of SIX2 haploinsufficiency is widened. Moreover, 2p21 microdeletions with SIX2 haploinsufficiency appear to lead to a recognizable phenotype with facial features resembling blepharophimosis-ptosis-epicanthus inversus syndrome.
DDX3-mediated colorectal cancer aggressiveness and cetuximab resistance were regulated by the YAP1/SIX2 axis in KRAS-wild type cells and further confirmed in animal models.
elevated expressions of SIX2, SIX4 (show SIX4 Antibodies), and SIX6 (show SIX6 Antibodies) predicted poor overall survival (OS) in NSCLC and poor relapse-free survival (RFS) in lung adenocarcinoma
these findings delineate the important function of the TGFbeta (show TGFB1 Antibodies) signaling pathway in the early development of kidney and TbetaRII was shown to be able to promote the expression of Six2 through Smad3 (show SMAD3 Antibodies) mediating transcriptional regulation and in turn activate the proliferation of MM cells.
We suggest SIX2 haploinsufficiency as a potential congenital factor could be attributed to developmental malformation of the middle ear ossicles and upper eyelid.
SIX2 deletion is associated with frontonasal dysplasia syndrome.
SIX2 overexpression and concomitantly decreased promoter methylation.
in tumors with DGCR8 (show DGCR8 Antibodies) E518K and DROSHA (show DROSHA Antibodies) exon 29 (miRNAPG-HS) mutations ... greater prevalence of tumors with blastemal predominant histology in patients with miRNAPG-HS and/or SIX1 (show SIX1 Antibodies)/2 Q177R mutations
Recurrent mutations included a hotspot mutation (Q177R) in the homeo-domain of SIX1 (show SIX1 Antibodies) and SIX2 in tumors with high proliferative potential (18.1% of blastemal cases); mutations in the DROSHA (show DROSHA Antibodies)/DGCR8 (show DGCR8 Antibodies) microprocessor genes
Embryonic day 18.5 Six2Frs2alphaKO kidneys were hypoplastic and not cystic, postnatal day (P) 7 mutants had proximal tubular-derived cysts that nearly replaced the renal parenchyma by P21 (show D4S234E Antibodies). Mutants had high proximal tubular proliferation rates and interstitial fibrosis, similar to known polycystic kidney disease models.
GATA1 (show GATA1 Antibodies) may be a potential regulator of Six2-maintained population of nephron progenitor cells.
Six2 mediates the protective effects of GDNF on damaged DA neurons by regulating Smurf1 (show SMURF1 Antibodies) expression.
Differentiation of nephron progenitors requires downregulation of Six2, a transcription factor required for progenitor maintenance, and that Notch (show NOTCH1 Antibodies) signaling is necessary and sufficient for Six2 downregulation.
Zeb1 (show ZEB1 Antibodies) promotes proliferation and apoptosis and inhibits the migration of metanephric mesenchyme cells, in association with Six2.
In Six2-positive nephrogenic progenitors, GLI3 (show GLI3 Antibodies) repressor decreased progenitor cell proliferation reducing the number of nephrogenic precursor structures in the Pallister-Hall syndrome mouse model.
Mechanistically, LIF (show LIF Antibodies) activates STAT (show STAT1 Antibodies), which binds to a Stat (show STAT1 Antibodies) consensus sequence in the Six2 proximal promoter and sustains SIX2 levels.
Dicer (show DICER1 Antibodies) ablation in the early metanephric mesenchyme results in severe renal dysgenesis despite normal initial specification of nephron progenitors and ureteric bud outgrowth.
miR181c downregulates the expression of Six2, restrain the proliferation and promote the apoptosis that even makes the nephron progenitor phenotype lose MM cells, suggesting a potential role of miR181c during the kidney development.
results reveal a functional link between Eya1 (show EYA1 Antibodies), Six2, and Myc (show MYC Antibodies) in driving the expansion and maintenance of the multipotent progenitors during nephrogenesis
This gene is a member of the vertebrate gene family which encode proteins homologous to the Drosophila 'sine oculis' homeobox protein. The encoded protein is a transcription factor which, like other members of this gene family, may be involved in limb or eye development.
homeobox protein SIX2
, sine oculis homeobox homolog 2
, sine oculis-related homeobox 2 homolog
, sine oculis-related homeobox 2
, SIX homeobox 2b
, sine oculis-related homeobox 2b