Sorting Nexin 3 Protein (SNX3) (AA 3-162, full length) (GST tag)

Catalog No. ABIN1095754

Product Details

Target: Sorting Nexin 3 (SNX3)

Protein Type: Recombinant

Protein Characteristics: AA 3-162, full length

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This Sorting Nexin 3 protein is labelled with GST tag.

Application: ELISA

Sequence: ETVADTRRLI TKPQNLNDAY GPPSNFLEID VSNPQTVGVG RGRFTTYEIR VKTNLPIFKL KESTVRRRYS DFEWLRSELE RESKVVVPPL PGKAFLRQLP FRGDDGIFDD NFIEERKQGL EQFINKVAGH PLAQNERCLH MFLQDEIIDK SYTPSKIRHA

Characteristics: Please inquire if you are interested in this recombinant protein expressed in E. coli, mammalien cells or by baculovirus infection. Be aware about differences in price and lead time.

Purity: 90 %

Application Details

Comment:

The yeast protein expression system is the most economical and efficient eukaryotic system for secretion and intracellular expression. A protein expressed by the mammalian cell system is of very high-quality and close to the natural protein. But the low expression level, the high cost of medium and the culture conditions restrict the promotion of mammalian cell expression systems. The yeast protein expression system serve as a eukaryotic system integrate the advantages of the mammalian cell expression system. A protein expressed by yeast system could be modificated such as glycosylation, acylation, phosphorylation and so on to ensure the native protein conformation. It can be used to produce protein material with high added value that is very close to the natural protein. Our proteins produced by yeast expression system has been used as raw materials for downstream preparation of monoclonal antibodies.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: 0.2-2 mg/mL

Buffer: Tris-based buffer, 50 % glycerol

Handling Advice: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week

Storage: -20 °C

Storage Comment: Store at -20 °C for extended storage, conserve at -20 °C or -80 °C

References

Xu, Hortsman, Seet, Wong, Hong: "SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P." in: Nature cell biology, Vol. 3, Issue 7, pp. 658-66, (2001) (PubMed).

Haft, de la Luz Sierra, Barr, Haft, Taylor: "Identification of a family of sorting nexin molecules and characterization of their association with receptors." in: Molecular and cellular biology, Vol. 18, Issue 12, pp. 7278-87, (1998) (PubMed).

Target Details

Target: Sorting Nexin 3 (SNX3)

Alternative Name: Sorting nexin-3 protein (SNX3 Products)

Synonyms: SNX3 Protein, sdp3 Protein, Grd19 Protein, snx3a Protein, wu:fb53a08 Protein, zgc:123189 Protein, MCOPS8 Protein, SDP3 Protein, sorting nexin 3 Protein, sorting nexin 3 L homeolog Protein, potential phosphoinositide-binding protein similar to S. cerevisiae GRD19 (YOR357C) late Golgi protein involved in retrieval of proteins from prevacuolar compartment; same as cosmid orf Ca41C10.03 Protein, SNX3 Protein, snx3.L Protein, snx3 Protein, GRD19 Protein, Snx3 Protein

Background: Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol-3-phosphate (PtdIns(P3)). Plays a role in protein transport between cellular compartments. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G By similarity. Not involved in EGFR degradation.

Molecular Weight: 45.9 kD

UniProt: O60493