TACR1 Protein (AA 1-29) (GST tag)

Catalog No. ABIN1095761

Product Details

Target: TACR1 (Tachykinin Receptor 1 (TACR1))

Protein Type: Recombinant

Protein Characteristics: AA 1-29

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This TACR1 protein is labelled with GST tag.

Application: ELISA

Sequence: MDNVLPVDSD LSPNISTNTS EPNQFVQPA

Characteristics: Please inquire if you are interested in this recombinant protein expressed in E. coli, mammalien cells or by baculovirus infection. Be aware about differences in price and lead time.

Purity: 90 %

Application Details

Comment:

The yeast protein expression system is the most economical and efficient eukaryotic system for secretion and intracellular expression. A protein expressed by the mammalian cell system is of very high-quality and close to the natural protein. But the low expression level, the high cost of medium and the culture conditions restrict the promotion of mammalian cell expression systems. The yeast protein expression system serve as a eukaryotic system integrate the advantages of the mammalian cell expression system. A protein expressed by yeast system could be modificated such as glycosylation, acylation, phosphorylation and so on to ensure the native protein conformation. It can be used to produce protein material with high added value that is very close to the natural protein. Our proteins produced by yeast expression system has been used as raw materials for downstream preparation of monoclonal antibodies.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: 0.2-2 mg/mL

Buffer: Tris-based buffer, 50 % glycerol

Handling Advice: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week

Storage: -20 °C

Storage Comment: Store at -20 °C for extended storage, conserve at -20 °C or -80 °C

References

Takeda, Chou, Takeda, Sachais, Krause: "Molecular cloning, structural characterization and functional expression of the human substance P receptor." in: Biochemical and biophysical research communications, Vol. 179, Issue 3, pp. 1232-40, (1991) (PubMed).

Hopkins, Powell, Danks, Briggs, Graham: "Isolation and characterisation of the human lung NK-1 receptor cDNA." in: Biochemical and biophysical research communications, Vol. 180, Issue 2, pp. 1110-7, (1991) (PubMed).

Target Details

Target: TACR1 (Tachykinin Receptor 1 (TACR1))

Alternative Name: Substance-P receptor protein (TACR1 Products)

Synonyms: NK1R Protein, NKIR Protein, SPR Protein, TAC1R Protein, Nk1r Protein, Spr Protein, Tac1r Protein, nk1R Protein, Tacr1 Protein, ASPR Protein, tachykinin receptor 1 Protein, TACR1 Protein, Tacr1 Protein

Background: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.

Molecular Weight: 30.5 kD

UniProt: P25103

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration