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ASS1 Protein (AA 1-412) (His tag)

ASS1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN1096047
  • Target See all ASS1 Proteins
    ASS1 (Argininosuccinate Synthase 1 (ASS1))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 1-412
    Origin
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 4
    • 3
    • 2
    • 2
    • 2
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This ASS1 protein is labelled with His tag.
    Purpose
    Recombinant Human Argininosuccinate Synthase/ASS1 (N-6His)
    Sequence
    MGSSHHHHHH SSGLVPRGSH MSSKGSVVLA YSGGLDTSCI LVWLKEQGYD VIAYLANIGQ KEDFEEARKK ALKLGAKKVF IEDVSREFVE EFIWPAIQSS ALYEDRYLLG TSLARPCIAR KQVEIAQREG AKYVSHGATG KGNDQVRFEL SCYSLAPQIK VIAPWRMPEF YNRFKGRNDL MEYAKQHGIP IPVTPKNPWS MDENLMHISY EAGILENPKN QAPPGLYTKT QDPAKAPNTP DILEIEFKKG VPVKVTNVKD GTTHQTSLEL FMYLNEVAGK HGVGRIDIVE NRFIGMKSRG IYETPAGTIL YHAHLDIEAF TMDREVRKIK QGLGLKFAEL VYTGFWHSPE CEFVRHCIAK SQERVEGKVQ VSVLKGQVYI LGRESPLSLY NEELVSMNVQ GDYEPTDATG FININSLRLK EYHRLQSKVT AK
    Characteristics
    Recombinant Human Argininosuccinate Synthase/ASS1 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Lys412) of Human ASS1 fused with a 6His tag at the C-terminus.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Sterility
    0.2 μm filtered
    Endotoxin Level
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
    Top Product
    Discover our top product ASS1 Protein
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Reconstitution
    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Buffer
    Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 50 mM Imidazole, 1 mM DTT, 40 % Glycerol, pH 7.5.
    Preservative
    Dithiothreitol (DTT)
    Precaution of Use
    This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    Storage
    -80 °C
    Storage Comment
    Store at < -20°C, stable for 6 months after receipt.
    Please minimize freeze-thaw cycles.
    Expiry Date
    6 months
  • Target
    ASS1 (Argininosuccinate Synthase 1 (ASS1))
    Alternative Name
    Argininosuccinate Synthase/ASS1 (ASS1 Products)
    Synonyms
    ASS Protein, CTLN1 Protein, AA408052 Protein, Ass-1 Protein, fold Protein, ASSA Protein, Ass Protein, ass Protein, zgc:92051 Protein, wu:fb95a04 Protein, wu:fc01e08 Protein, argininosuccinate synthase 1 Protein, argininosuccinate synthetase 1 Protein, argininosuccinate synthase 1 S homeolog Protein, ASS1 Protein, Ass1 Protein, ass1.S Protein, ass1 Protein
    Sub Type
    Fusionprotein
    Background
    Argininosuccinate Synthase (ASS1) is an urea cycle enzyme with a tetrameric structure composed of identical subunits. ASS1 is involved in the synthesis of arginine and catalyzes that condensation of citrulline and aspartate to argininosuccinate using ATP. ASS1 is important to the urea cycle as it catalyzes the important second last step in the arginine biosynthetic pathway. ASS1 mainly expressed in periportal hepatocytes, but also in most other body tissues. A deficiency of ASS1 causes citrullinemia (CTLN1), an autosomal recessive disease which is characterized by severe vomiting spells and mental retardation.
    Alternative Names: Argininosuccinate Synthase, Citrulline--Aspartate Ligase, ASS1, ASS
    Molecular Weight
    42.8 kDa
    UniProt
    P00966
    Pathways
    Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin
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