Cathepsin S Protein (CTSS) (AA 17-331) (His tag)

Catalog No. ABIN1096245

This Recombinant Cathepsin S protein is produced in Human Cells.

Quick Overview for Cathepsin S Protein (CTSS) (AA 17-331) (His tag) (ABIN1096245)

Target: Cathepsin S (CTSS)

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 17-331

Purification tag / Conjugate: This Cathepsin S protein is labelled with His tag.

Purpose: Recombinant Human Cathepsin S/CTSS (C-6His)

Sequence: QLHKDPTLDH HWHLWKKTYG KQYKEKNEEA VRRLIWEKNL KFVMLHNLEH SMGMHSYDLG MNHLGDMTSE EVMSLMSSLR VPSQWQRNIT YKSNPNWILP DSVDWREKGC VTEVKYQGSC GACWAFSAVG ALEAQLKLKT GKLVSLSAQN LVDCSTEKYG NKGCNGGFMT TAFQYIIDNK GIDSDASYPY KAMDQKCQYD SKYRAATCSK YTELPYGRED VLKEAVANKG PVSVGVDARH PSFFLYRSGV YYEPSCTQNV NHGVLVVGYG DLNGKEYWLV KNSWGHNFGE EGYIRMARNK GNHCGIASFP SYPEIVDHHH HHH

Characteristics:

Recombinant Human Cathepsin S/CTSS (C-6His)

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM MES, 150 mM NaCl, 10 % Glycerol, pH 5.5.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: -80 °C

Storage Comment: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Expiry Date: 6 months

Target Details

Target: Cathepsin S (CTSS)

Alternative Name: Cathepsin S

Background: Recombinant Human Cathepsin S is produced with our mammalian expression system in human cells. The target protein is expressed with the full length sequence of Human CTSS fused with a polyhistidine tag at the C-terminus.
Cathepsin S is a lysosomal enzyme that belongs to the papain family of cysteine proteases. This protein is expressed by antigen presenting cells including macrophages, B-lymphocytes, dendritic cells and microglia. Moreover, cathepsin S is expressed in some epithelial cells. Compared with the abundant cathepsins B, L and H, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicated that cathepsin S generates A β from amyloidogenic fragments of β APP in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer's disease (AD) and Down Syndrome (DS).

Molecular Weight: 36.89 kDa

UniProt: P25774

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades