FBP1 Protein (AA 2-338) (His tag)

Catalog No. ABIN1096624

Product Details

Target: FBP1 (Fructose-1,6-Bisphosphatase 1 (FBP1))

Protein Type: Recombinant

Protein Characteristics: AA 2-338

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This FBP1 protein is labelled with His tag.

Purpose: Recombinant Human Fructose-1,6-Bisphosphatase 1/FBPase 1 (E. coli, C-6His)

Sequence: ADQAPFDTDV NTLTRFVMEE GRKARGTGEL TQLLNSLCTA VKAISSAVRK AGIAHLYGIA GSTNVTGDQV KKLDVLSNDL VMNMLKSSFA TCVLVSEEDK HAIIVEPEKR GKYVVCFDPL DGSSNIDCLV SVGTIFGIYR KKSTDEPSEK DALQPGRNLV AAGYALYGSA TMLVLAMDCG VNCFMLDPAI GEFILVDKDV KIKKKGKIYS LNEGYARDFD PAVTEYIQRK KFPPDNSAPY GARYVGSMVA DVHRTLVYGG IFLYPANKKS PNGKLRLLYE CNPMAYVMEK AGGMATTGKE AVLDVIPTDI HQRAPVILGS PDDVLEFLKV YEKHSAQVEH HHHHH

Characteristics: Recombinant Human Fructose-1,6-Bisphosphatase 1/FBPase 1 is produced with our E. coli expression system. The target protein is expressed with sequence (Ala2-Gln338) of Human FBPase 1.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 200 mM NaCl, 1 mM DTT, 1 mM EDTA, 20 % Glycerol, pH 8.0.

Preservative: Dithiothreitol (DTT)

Precaution of Use: This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: -80 °C

Storage Comment: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Expiry Date: 6 months

Target Details

Target: FBP1 (Fructose-1,6-Bisphosphatase 1 (FBP1))

Alternative Name: Fructose-1,6-Bisphosphatase 1/FBPase 1 (FBP1 Products)

Synonyms: FBP Protein, Fbp-2 Protein, Fbp2 Protein, Fbp3 Protein, FBP1 Protein, fbp2 Protein, Fdp Protein, CG10611 Protein, CG31692 Protein, Dmel\\CG31692 Protein, FbPase Protein, fbp1 Protein, cb598 Protein, fb57b01 Protein, zgc:64127 Protein, id:ibd1091 Protein, wu:fb17g10 Protein, wu:fb57b01 Protein, fdp Protein, xcc-b100_0105 Protein, fbp1l Protein, fk92h02 Protein, wu:fk92h02 Protein, zgc:64096 Protein, fbp Protein, fbp1.S Protein, fructose-bisphosphatase 1 Protein, fructose bisphosphatase 1 Protein, Fructose-1,6-bisphosphatase Protein, fructose-1,6-bisphosphatase Protein, fructose-1,6-bisphosphatase 1 Protein, fructose-bisphosphatase class I Protein, fructose-1,6-bisphosphatase 1b Protein, fbp Protein, fructose-1,6-bisphosphatase 1a Protein, fructose-bisphosphatase 1 L homeolog Protein, FBP1 Protein, Fbp1 Protein, fbp1 Protein, LOC100136618 Protein, RR_RS07410 Protein, fbp Protein, fbp1b Protein, fbp1a Protein, fbp1.L Protein

Background: Fructose-1,6-Bisphosphatase 1 (FBPase 1) is a member of the FBPase class 1 family. FBPase 1 is a gluconeogenesis regulatory protein, which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. FBPase 1 can assume an active R-state, or an inactive T-state. FBPase 1 deficiency is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis in newborn infants or young children. FBPase 1 coupled with phosphofructokinase (PFK) is involved in the metabolism of pancreatic islet cells.
Alternative Names: Fructose-1,6-Bisphosphatase 1, FBPase 1, D-Fructose-1,6-Bisphosphate 1-Phosphohydrolase 1, FBP1, FBP

Molecular Weight: 37.89 kDa

UniProt: P09467

Pathways: Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Dicarboxylic Acid Transport