FLRT1 Protein (AA 21-524) (His tag)

Catalog No. ABIN1096678

Product Details

Target: FLRT1 (Fibronectin Leucine Rich Transmembrane Protein 1 (FLRT1))

Protein Type: Recombinant

Protein Characteristics: AA 21-524

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This FLRT1 protein is labelled with His tag.

Purpose: Recombinant Human Fibronectin Leucine Rich Transmembrane Protein 1/FLRT1 (C-6His)

Sequence: IDSTTCPSVC RCDNGFIYCN DRGLTSIPAD IPDDATTLYL QNNQINNAGI PQDLKTKVNV QVIYLYENDL DEFPINLPRS LRELHLQDNN VRTIARDSLA RIPLLEKLHL DDNSVSTVSI EEDAFADSKQ LKLLFLSRNH LSSIPSGLPH TLEELRLDDN RISTIPLHAF KGLNSLRRLV LDGNLLANQR IADDTFSRLQ NLTELSLVRN SLAAPPLNLP SAHLQKLYLQ DNAISHIPYN TLAKMRELER LDLSNNNLTT LPRGLFDDLG NLAQLLLRNN PWFCGCNLMW LRDWVKARAA VVNVRGLMCQ GPEKVRGMAI KDITSEMDEC FETGPQGGVA NAAAKTTASN HASATTPQGS LFTLKAKRPG LRLPDSNIDY PMATGDGAKT LAIHVKALTA DSIRITWKAT LPASSFRLSW LRLGHSPAVG SITETLVQGD KTEYLLTALE PKSTYIICMV TMETSNAYVA DETPVCAKAE TADSYGPTTT LNQEQNAGPM ASLPVDHHHH HH

Characteristics: Recombinant Human Leucine-Rich Repeat Transmembrane Protein FLRT1/FLRT1 is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Ile21-Pro524) of Human FLRT1 fused with a polyhistidine tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 3 months

Target Details

Target: FLRT1 (Fibronectin Leucine Rich Transmembrane Protein 1 (FLRT1))

Alternative Name: flrt1 (FLRT1 Products)

Synonyms: MGC84476 Protein, FLRT1 Protein, sc:d0318 Protein, AW742165 Protein, D630040I23Rik Protein, RGD1565152 Protein, fibronectin leucine rich transmembrane protein 1 S homeolog Protein, fibronectin leucine rich transmembrane protein 1 Protein, fibronectin leucine rich transmembrane protein 1b Protein, flrt1.S Protein, FLRT1 Protein, flrt1b Protein, flrt1 Protein, Flrt1 Protein

Sub Type: Fusionprotein

Background: Fibronectin Leucine Rich Transmembrane Protein 1 (FLRT1) is a member of the Fibronectin Leucine Rich Transmembrane protein (FLRT) family. There are three fibronectin leucine-rich repeat transmembrane (FLRT) proteins: FLRT1, FLRT2 and FLRT3, all contain 10 leucine-rich repeats (LRR), a type III fibronectin (FN) domain, followed by the transmembrane region, and a short cytoplasmic tail. FLRT proteins have dual properties as regulators of cell adhesion and potentiators of fibroblast growth factor (FGF) mediated signalling. The fibronectin domain of all three FLRTs can bind FGF receptors. This binding is thought to regulate FGF signaling during development. The LRR domains are responsible for both the localization of FLRTs in areas of cell contact and homotypic cell association. FLRT1 is expressed at brain compartmental boundaries. FLRT1 is a target for tyrosine phosphorylation mediated by FGFR1 and implicate a non-receptor Src family kinase (SFK).
Alternative Names: Leucine-Rich Repeat Transmembrane Protein FLRT1, Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 1, FLRT1

Molecular Weight: 56.52 kDa

UniProt: Q9NZU1