Oncostatin M Receptor Protein (OSMR) (AA 28-739) (His tag)
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- Target See all Oncostatin M Receptor (OSMR) Proteins
- Oncostatin M Receptor (OSMR)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 28-739
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Origin
- Human
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Source
- Human Cells
- Purification tag / Conjugate
- This Oncostatin M Receptor protein is labelled with His tag.
- Purpose
- Recombinant Human Oncostatin-M-Specific Receptor Subunit β/OSMRB/IL-31RB (C-6His)
- Sequence
- ERLPLTPVSL KVSTNSTRQS LHLQWTVHNL PYHQELKMVF QIQISRIETS NVIWVGNYST TVKWNQVLHW SWESELPLEC ATHFVRIKSL VDDAKFPEPN FWSNWSSWEE VSVQDSTGQD ILFVFPKDKL VEEGTNVTIC YVSRNIQNNV SCYLEGKQIH GEQLDPHVTA FNLNSVPFIR NKGTNIYCEA SQGNVSEGMK GIVLFVSKVL EEPKDFSCET EDFKTLHCTW DPGTDTALGW SKQPSQSYTL FESFSGEKKL CTHKNWCNWQ ITQDSQETYN FTLIAENYLR KRSVNILFNL THRVYLMNPF SVNFENVNAT NAIMTWKVHS IRNNFTYLCQ IELHGEGKMM QYNVSIKVNG EYFLSELEPA TEYMARVRCA DASHFWKWSE WSGQNFTTLE AAPSEAPDVW RIVSLEPGNH TVTLFWKPLS KLHANGKILF YNVVVENLDK PSSSELHSIP APANSTKLIL DRCSYQICVI ANNSVGASPA SVIVISADPE NKEVEEERIA GTEGGFSLSW KPQPGDVIGY VVDWCDHTQD VLGDFQWKNV GPNTTSTVIS TDAFRPGVRY DFRIYGLSTK RIACLLEKKT GYSQELAPSD NPHVLVDTLT SHSFTLSWKD YSTESQPGFI QGYHVYLKSK ARQCHPRFEK AVLSDGSECC KYKIDNPEEK ALIVDNLKPE SFYEFFITPF TSAGEGPSAT FTKVTTPDEH SSVDHHHHHH
- Characteristics
- Recombinant Human Oncostatin-M-Specific Receptor Subunit beta/OSMRB produced by transfected human cells is a secreted protein with sequence (Glu28-Ser739) of Human OSMRB fused with a polyhistidine tag at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Sterility
- 0.2 μm filtered
- Endotoxin Level
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
- Top Product
- Discover our top product OSMR Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
- Handling Advice
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- Storage
- 4 °C/-20 °C/-80 °C
- Storage Comment
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Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months. - Expiry Date
- 3 months
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- Target
- Oncostatin M Receptor (OSMR)
- Alternative Name
- Il-31-Rb (OSMR Products)
- Synonyms
- OSMRB Protein, PLCA1 Protein, oncostatin M receptor Protein, OSMR Protein, Osmr Protein
- Sub Type
- Fusionprotein
- Background
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Oncostatin-M-Specific Receptor Subunit beta (OSMRbeta) is a 150 - 180 kDa member of the IL-6 receptor family. OSMRbeta associates with gp130 to form the type II OSM receptor, the receptor is responsive to OSM. Gp130 subunit is shared by other IL-6 family cytokine receptors, and OSMRbeta associates with gp130-like receptor (GPL) to form a receptor complex responsive to IL-31. The human OSMRbeta cDNA encodes a 979 amino acid (aa) precursor, the precursor includes a 27 aa signal sequence, a 712 aa extracellular domain (ECD), a 22 aatransmembrane segment, and a 218 aa cytoplasmic domain. The ECD contains one partial and one complete hematopoietin domain, an Ig-like domain, and three Fibronectin type-III domains.
Alternative Names: Oncostatin-M-Specific Receptor Subunit Beta, Interleukin-31 Receptor Subunit Beta, IL-31 Receptor Subunit Beta, IL-31R Subunit Beta, IL-31R-Beta, IL-31RB, OSMR, OSMRB - Molecular Weight
- 82.03 kDa
- UniProt
- Q99650
- Pathways
- JAK-STAT Signaling, Growth Factor Binding
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