OLR1 Protein (AA 61-273) (His tag)

Catalog No. ABIN1097095

Product Details

Target: OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))

Protein Type: Recombinant

Protein Characteristics: AA 61-273

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This OLR1 protein is labelled with His tag.

Purpose: Recombinant Human Oxidized Low-Density Lipoprotein Receptor 1/OLR1 (C-6His)

Sequence: SQVSDLLTQE QANLTHQKKK LEGQISARQQ AEEASQESEN ELKEMIETLA RKLNEKSKEQ MELHHQNLNL QETLKRVANC SAPCPQDWIW HGENCYLFSS GSFNWEKSQE KCLSLDAKLL KINSTADLDF IQQAISYSSF PFWMGLSRRN PSYPWLWEDG SPLMPHLFRV RGAVSQTYPS GTCAYIQRGA VYAENCILAA FSICQKKANL RAQVDHHHHH H

Characteristics: Recombinant Human Oxidized Low-Density Lipoprotein Receptor 1/OLR1 produced by transfected human cellss is a secreted protein with sequence (Ser61-Gln273) of Human LOX-1/OLR1 fused with a polyhistidine tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 3 months

Target Details

Target: OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))

Alternative Name: lox-1 (OLR1 Products)

Synonyms: OLR1 Protein, LOX1 Protein, Olr1 Protein, CLEC8A Protein, LOXIN Protein, SCARE1 Protein, SLOX1 Protein, LOX-1 Protein, SR-EI Protein, Scare1 Protein, Oldlr1 Protein, Oldr1 Protein, PLOX-1 Protein, oxidized low density lipoprotein receptor 1 Protein, oxidized low density lipoprotein (lectin-like) receptor 1 Protein, OLR1 Protein, Olr1 Protein

Sub Type: Fusionprotein

Background: Oxidized Low-Density Lipoprotein Receptor 1 (Ox-LDL Receptor 1) is a secreted, single-pass type II membrane protein which belongs to the C-type lectin superfamily. Ox-LDL Receptor 1 is expressed at high levels in endothelial cells and vascular-rich organs such as placenta, lung, liver, brain, aortic intima, bone marrow, spinal cord and substantia nigra. The expression of Ox-LDL Receptor 1 is induced by inflammatory cytokines such as TNF, IFNG and IL6 by pathological conditions, such as hyperlipidemia, hypertension and diabetes mellitus. Ox-LDL Receptor 1 mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (OxLDL) by vascular endothelial cells. Ox-LDL Receptor 1 association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. Ox-LDL Receptor 1 also binds to oxLDL, which acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. It also participates in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation.
Alternative Names: Oxidized Low-Density Lipoprotein Receptor 1, Ox-LDL Receptor 1, C-Type Lectin Domain Family 8 Member A, Lectin-Like Oxidized LDL Receptor 1, LOX-1, Lectin-Like oxLDL Receptor 1, hLOX-1, Lectin-Type Oxidized LDL Receptor 1, OLR1, CLEC8A, LOX1

Molecular Weight: 25.39 kDa

UniProt: P78380