SENP8 Protein (AA 1-212) (His tag)

Catalog No. ABIN1097211

Product Details

Target: SENP8 (SUMO/sentrin Specific Peptidase Family Member 8 (SENP8))

Protein Type: Recombinant

Protein Characteristics: AA 1-212

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This SENP8 protein is labelled with His tag.

Purpose: Recombinant Human Sentrin-Specific Protease 8/SENP8 (N-6His)

Sequence: MGSSHHHHHH SSGLVPRGSH MDPVVLSYMD SLLRQSDVSL LDPPSWLNDH IIGFAFEYFA NSQFHDCSDH VSFISPEVTQ FIKCTSNPAE IAMFLEPLDL PNKRVVFLAI NDNSNQAAGG THWSLLVYLQ DKNSFFHYDS HSRSNSVHAK QVAEKLEAFL GRKGDKLAFV EEKAPAQQNS YDCGMYVICN TEALCQNFFR QQTESLLQLL TPAYITKKRG EWKDLIATLA KK

Characteristics: Recombinant Human Sentrin-Specific Protease 8/SENP8 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Lys212) of Human SENP8.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: -80 °C

Storage Comment: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Expiry Date: 6 months

Target Details

Target: SENP8 (SUMO/sentrin Specific Peptidase Family Member 8 (SENP8))

Alternative Name: Sentrin-Specific Protease 8/SENP8 (SENP8 Products)

Synonyms: den1 Protein, nedp1 Protein, prsc2 Protein, MGC84956 Protein, F15L12.8 Protein, F15L12_8 Protein, 9130010J17Rik Protein, AU020827 Protein, Den1 Protein, Nedp1 Protein, Prsc2 Protein, DEN1 Protein, NEDP1 Protein, PRSC2 Protein, SUMO/sentrin peptidase family member, NEDD8 specific L homeolog Protein, Cysteine proteinases superfamily protein Protein, SUMO/sentrin specific peptidase 8 Protein, SUMO/sentrin peptidase family member, NEDD8 specific Protein, senp8.L Protein, AT5G60190 Protein, Senp8 Protein, SENP8 Protein

Background: Sentrin-Specific Protease 8 (SENP8) mediates the reversible covalent modification of proteins by NEDD8. SENP8 catalyzes the full-length NEDD8 to generate its mature form and deconjugation of NEDD8 from targeted proteins such as CUL2 , CUL4A in vivo, or p53. but it does not show activity against ubiquitin or SUMO proteins.
Alternative Names: Sentrin-Specific Protease 8, Deneddylase-1, NEDD8-Specific Protease 1, Protease Cysteine 2, Sentrin/SUMO-Specific Protease SENP8, SENP8, DEN1, NEDP1, PRSC2

Molecular Weight: 26.24 kDa

UniProt: Q96LD8