SLAMF6 Protein (AA 28-225) (His tag)

Catalog No. ABIN1097248

Product Details

Target: SLAMF6 (SLAM Family Member 6 (SLAMF6))

Protein Type: Recombinant

Protein Characteristics: AA 28-225

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This SLAMF6 protein is labelled with His tag.

Purpose: Recombinant Human SLAM Family Member 6/SLAMF6/CD352/NTB-A (C-6His)

Sequence: LMVNGILGES VTLPLEFPAG EKVNFITWLF NETSLAFIVP HETKSPEIHV TNPKQGKRLN FTQSYSLQLS NLKMEDTGSY RAQISTKTSA KLSSYTLRIL RQLRNIQVTN HSQLFQNMTC ELHLTCSVED ADDNVSFRWE ALGNTLSSQP NLTVSWDPRI SSEQDYTCIA ENAVSNLSFS VSAQKLCEDV KIQYTDTKVD HHHHHH

Characteristics:

Recombinant Human SLAM Family Member 6/SLAMF6/CD352/NTB-A (C-6His)

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: SLAMF6 (SLAM Family Member 6 (SLAMF6))

Alternative Name: SLAM Family Member 6/SLAMF6 (SLAMF6 Products)

Synonyms: SLAMF6 Protein, CD352 Protein, KALI Protein, KALIb Protein, Ly108 Protein, NTB-A Protein, NTBA Protein, SF2000 Protein, KAL1 Protein, KAL1b Protein, RGD1561848 Protein, SLAM family member 6 Protein, SLAMF6 Protein, Slamf6 Protein

Background: Recombinant Human SLAM Family Member 6/SLAMF6 is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Gln22-Met226) of Human SLAMF6 fused with a polyhistidine tag at the C-terminus.
SLAM Family Member 6 (SLAMF6) is a 60 kDa single-pass type I membrane protein that belongs to the SLAM subgroup of the CD2 family. Human SLAMF6/ NTB-A contains a 205 AA extracellular domain (ECD) with one Ig-like V-set and one Ig-like C2-set domain, a 21 AA transmembrane segment and an 84 AA cytoplasmic domain, with two immunoreceptor tyrosine-based switch motifs. SLAMF6 is a homodimer. SLAMF6 can interact with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. Phosphorylation-dependent NTB-A association with SAP is required for full production of IFN-γ by NK cells and independent of EAT-2 binding. It Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. On B cells, NTB-A modulates immunoglobulin class switching and the balance between tolerance and autoimmunity.

Molecular Weight: 23.98 kDa

UniProt: Q96DU3