PRTN3 Protein (AA 26-249) (His tag)
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- Target See all PRTN3 Proteins
- PRTN3 (Proteinase 3 (PRTN3))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 26-249
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Origin
- Human
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Source
- Human Cells
- Purification tag / Conjugate
- This PRTN3 protein is labelled with His tag.
- Purpose
- Recombinant Human Proteinase 3/PRTN3/Myeloblastin (C-6His)
- Sequence
- AEIVGGHEAQ PHSRPYMASL QMRGNPGSHF CGGTLIHPSF VLTAAHCLRD IPQRLVNVVL GAHNVRTQEP TQQHFSVAQV FLNNYDAENK LNDVLLIQLS SPANLSASVA TVQLPQQDQP VPHGTQCLAM GWGRVGAHDP PAQVLQELNV TVVTFFCRPH NICTFVPRRK AGICFGDSGG PLICDGIIQG IDSFVIWGCA TRLFPDFFTR VALYVDWIRS TLRRVDHHHH HH
- Characteristics
- Recombinant Human Proteinase 3/PRTN3 is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Ala26-Arg249) of Human PRTN3 fused with a polyhistidine tag at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Sterility
- 0.2 μm filtered
- Endotoxin Level
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
- Top Product
- Discover our top product PRTN3 Protein
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Proteinase 3 (PRTN3) (AA 1-256) protein (GST tag)
PRTN3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Proteinase 3 (PRTN3) (AA 139-248) protein (GST tag)PRTN3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Proteinase 3 (PRTN3) (AA 28-248) protein (His tag)Crystallography grade PRTN3 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Proteinase 3 (PRTN3) (AA 30-250) protein (His tag)Crystallography grade PRTN3 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Proteinase 3 (PRTN3) (AA 28-248) protein (GST tag)PRTN3 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Reconstitution
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - Buffer
- Supplied as a 0.2 μm filtered solution of 10 mM TrisHCl, 150 mM NaCl, 10 % Glycerol, pH 8.0.
- Handling Advice
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- Storage
- -80 °C
- Storage Comment
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Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles. - Expiry Date
- 6 months
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- Target
- PRTN3 (Proteinase 3 (PRTN3))
- Alternative Name
- proteinase-3 (PRTN3 Products)
- Synonyms
- ela2 Protein, MGC132250 Protein, ACPA Protein, AGP7 Protein, C-ANCA Protein, CANCA Protein, MBN Protein, MBT Protein, NP-4 Protein, NP4 Protein, P29 Protein, PR-3 Protein, PR3 Protein, mPR3 Protein, proteinase 3 L homeolog Protein, proteinase 3 Protein, prtn3.L Protein, PRTN3 Protein, Prtn3 Protein
- Sub Type
- Fusionprotein
- Background
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Proteinase-3 is a neutral serine proteinase that belongs to the peptidase S1 family and Elastase subfamily. It contains one peptidase S1 domain and it is expressed mainly in neutrophil granulocytes. The primary function of Proteinase-3 is thought to be degradation of extracellular proteins at sites of inflammation, but excessive or prolonged proteolytic activity may cause harmful effects in the body. It is the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.
Alternative Names: Myeloblastin, AGP7, C-ANCA Antigen, Leukocyte Proteinase 3, PR-3, PR3, Neutrophil Proteinase 4, NP-4, P29, Wegener Autoantigen, PRTN3, MBN - Molecular Weight
- 25.64 kDa
- UniProt
- P24158
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