TTR Protein (AA 21-147) (His tag)

Catalog No. ABIN1097694

Product Details

Target: TTR (Transthyretin (TTR))

Protein Type: Recombinant

Protein Characteristics: AA 21-147

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This TTR protein is labelled with His tag.

Purpose: Recombinant Human Transthyretin/TTR/PALB (C-6His)

Sequence: GPTGTGESKC PLMVKVLDAV RGSPAINVAV HVFRKAADDT WEPFASGKTS ESGELHGLTT EEEFVEGIYK VEIDTKSYWK ALGISPFHEH AEVVFTANDS GPRRYTIAAL LSPYSYSTTA VVTNPKEVDH HHHHH

Characteristics: Recombinant Human Transthyretin/TTR produced by transfected human cells is a secreted protein with sequence (Gly21-Glu147) of Human TTR fused with a polyhistidine tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM TrisHCl, 150 mM NaCl, pH 8.0.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 3 months

Target Details

Target: TTR (Transthyretin (TTR))

Alternative Name: transthyretin (TTR Products)

Synonyms: zgc:103583 Protein, TTR Protein, LOC100226992 Protein, CTS Protein, CTS1 Protein, HsT2651 Protein, PALB Protein, TBPA Protein, AA408768 Protein, AI787086 Protein, D17860 Protein, prealbumin Protein, Lr1 Protein, Tbpa Protein, Prealbumin Protein, xTTR Protein, transthyretin (prealbumin, amyloidosis type I) Protein, transthyretin Protein, Transthyretin Protein, transthyretin (prealbumin, amyloidosis type 1) Protein, transthyretin-like Protein, transthyretin L homeolog Protein, ttr Protein, TTR Protein, vpb38 Protein, MRAD2831_RS38185 Protein, Caci_4246 Protein, LOC100226992 Protein, Ttr Protein, ttr.L Protein

Sub Type: Fusionprotein

Background: Transthyretin is a secreted and cytoplasm protein which belongs to the Transthyretin family. Transthyretin is detected in serum and cerebrospinal fluid (at protein level). It is highly expressed in choroid plexus epithelial cells. It is also detected in retina pigment epithelium and liver. Each monomer of Transthyretin has two 4-stranded beta sheets and the shape of a prolate ellipsoid. Antiparallel beta-sheet interactions link monomers into dimers. A short loop from each monomer forms the main dimer-dimer interaction. These two pairs of loops separate the opposed, convex beta-sheets of the dimers to form an internal channel. Defects in Transthyretin are the cause of amyloidosis type 1 (AMYL1) which is a hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system.
Alternative Names: Transthyretin, ATTR, Prealbumin, TBPA, TTR, PALB

Molecular Weight: 14.8 kDa

UniProt: P02766

Pathways: Hormone Transport