PLAUR Protein (AA 23-303) (His tag)

Catalog No. ABIN1097763

Product Details

Target: PLAUR (Plasminogen Activator, Urokinase Receptor (PLAUR))

Protein Type: Recombinant

Protein Characteristics: AA 23-303

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This PLAUR protein is labelled with His tag.

Purpose: Recombinant Human Urokinase Plasminogen Activator Surface Receptor/uPAR (C-6His)

Sequence: LRCMQCKTNG DCRVEECALG QDLCRTTIVR LWEEGEELEL VEKSCTHSEK TNRTLSYRTG LKITSLTEVV CGLDLCNQGN SGRAVTYSRS RYLECISCGS SDMSCERGRH QSLQCRSPEE QCLDVVTHWI QEGEEGRPKD DRHLRGCGYL PGCPGSNGFH NNDTFHFLKC CNTTKCNEGP ILELENLPQN GRQCYSCKGN STHGCSSEET FLIDCRGPMN QCLVATGTHE PKNQSYMVRG CATASMCQHA HLGDAFSMNH IDVSCCTKSG CNHPDLDVQY RVDHHHHHH

Characteristics: Recombinant Human Urokinase Plasminogen Activator Surface Receptor/uPAR is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Leu23-Arg303) of Human PLAUR fused with a polyhistidine tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 3 months

Target Details

Target: PLAUR (Plasminogen Activator, Urokinase Receptor (PLAUR))

Alternative Name: upar (PLAUR Products)

Synonyms: Cd87 Protein, u-PAR Protein, uPAR Protein, CD87 Protein, U-PAR Protein, UPAR Protein, URKR Protein, Par Protein, Plaur3 Protein, uPAR-2 Protein, uPAR-3 Protein, PLAUR Protein, plasminogen activator, urokinase receptor Protein, Plaur Protein, PLAUR Protein

Sub Type: Fusionprotein

Background: The Urokinase Type Plasminogen Activator (uPA) receptor (uPAR) is a widely expressed receptor for urokinase plasminogen activator (uPA) and pro-uPA. uPAR / CD87 is a highly glycosylated, 55-60kDa integral membrane protein linked to the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor. uPAR is expressed by T-cells, NK cells, monocytes, and neutrophils as well as non-hematopoietic cells that include vascular endothelial cells, fibroblasts, smooth muscle cells, keratinocytes, placental trophoblasts, hepatocytes, and a wide variety of tumor cells (including breast, colon, and prostate carcinoma, melanoma). It plays a critical role in the regulation of cell-surface plasminogen activation in physiological and pathological conditions, and it is also involved in cellular adhesion, the transmission of extracellular signals across the plasma membrane and the subsequent regulation of gene expression. uPAR has been implicated in several biological processes including angiogenesis, monocyte migration, cancer metastasis, trophoblast implantation, and wound healing. Human uPAR is encoded as a 313 amino acid residue polypeptide, excluding a 22 residue signal peptide and shows 60-70% similarity with the murine uPAR amino acid sequence although binding of uPA to uPAR shows strong species specificity.
Alternative Names: Urokinase Plasminogen Activator Surface Receptor, U-PAR, uPAR, Monocyte activation antigen Mo3, CD87, PLAUR, MO3, UPAR

Molecular Weight: 32.6 kDa

UniProt: Q03405

Pathways: Inositol Metabolic Process