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TSC22D3 Protein (His tag)

TSC22D3 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 85 % by SDS - PAGE SDS
Catalog No. ABIN1098422
  • Target See all TSC22D3 Proteins
    TSC22D3 (TSC22 Domain Family, Member 3 (TSC22D3))
    Protein Type
    Recombinant
    Origin
    • 5
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 3
    • 3
    • 2
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This TSC22D3 protein is labelled with His tag.
    Application
    SDS-PAGE (SDS)
    Purification
    purified by chromatography
    Purity
    > 85 % by SDS - PAGE
    Top Product
    Discover our top product TSC22D3 Protein
  • Comment

    Synonyms: TSC22 domain family protein 3, DIP, DSIPI, GILZ, hDIP, TSC-22R

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/ml (determined by Bradford assay)
    Buffer
    20 mM Tris-HCl buffer (pH 8.0) containing 0.15 M NaCl, 10% glycerol, 1 MM DTT
    Storage
    4 °C
    Storage Comment
    Avoid repeated freezing and thawing cycles.
  • Target
    TSC22D3 (TSC22 Domain Family, Member 3 (TSC22D3))
    Alternative Name
    TSC22D3 (TSC22D3 Products)
    Synonyms
    dsipi Protein, MGC53285 Protein, zgc:65831 Protein, zgc:77028 Protein, TSC22D3 Protein, GILZ Protein, gilz Protein, tsc-22r Protein, DIP Protein, DSIPI Protein, TSC-22R Protein, hDIP Protein, Dsip1 Protein, Gilz Protein, Tilz3 Protein, Dsipi Protein, DSIP Protein, TSC22 domain family member 3 L homeolog Protein, TSC22 domain family, member 3 Protein, TSC22 domain family member 3 Protein, tsc22d3.L Protein, tsc22d3 Protein, TSC22D3 Protein, Tsc22d3 Protein
    Background
    TSC22 domain family protein 3, also known as TSC22D3, protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, TSC22D3 plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, TSC22D3 inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Recombinant human TSC22D3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
    Molecular Weight
    17.2 kDa (157aa) confirmed by MALDI-TOF
    NCBI Accession
    NP_004080
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