ULBP2 Protein (His tag)
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- Target See all ULBP2 Proteins
- ULBP2 (UL16 Binding Protein 2 (ULBP2))
- Protein Type
- Recombinant
- Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This ULBP2 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Purity
- > 85 % by SDS - PAGE
- Top Product
- Discover our top product ULBP2 Protein
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UL16 Binding Protein 2 (ULBP2) (AA 26-217) protein (His-Avi Tag)
ULBP2 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
UL16 Binding Protein 2 (ULBP2) protein (His-Avi Tag,Biotin)ULBP2 Origin: Human Host: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
UL16 Binding Protein 2 (ULBP2) (AA 25-224) protein (His tag)ULBP2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
UL16 Binding Protein 2 (ULBP2) (AA 1-246) protein (GST tag)ULBP2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
UL16 Binding Protein 2 (ULBP2) (AA 26-216) protein (His tag)Crystallography grade ULBP2 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- Comment
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Synonyms: NKG2D ligand 2, N2DL2, RAET1H
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/ml (determined by Bradford assay)
- Buffer
- 20 mM Tris-HCl buffer (pH 8.0) containing 30% glycerol, 2 M Urea, 0.2 M NaCl, 2 mM DTT
- Storage
- 4 °C
- Storage Comment
- Avoid repeated freezing and thawing cycles.
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- Target
- ULBP2 (UL16 Binding Protein 2 (ULBP2))
- Alternative Name
- ULBP2 (ULBP2 Products)
- Synonyms
- N2DL2 Protein, RAET1H Protein, UL16 binding protein 2 Protein, NKG2D ligand 2-like Protein, ULBP2 Protein, LOC100355436 Protein
- Background
- ULBP2, also known as NKG2D ligand 2, belongs to the MHC class I family. This protein is ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. Recombinant human ULBP2 protein, fused to His-tag at N-terminus, was expressed in E.coli.
- Molecular Weight
- 24.3 kDa (216aa)
- NCBI Accession
- NP_079493
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