Acetylserotonin O-Methyltransferase (ASMT) protein (His tag)

Details for Product No. ABIN1098696, Supplier: Log in to see
Protein Name
  • asmt
  • ASMTY
  • HIOMT
  • HIOMTY
  • Hiomt
  • acetylserotonin O-methyltransferase 2
  • acetylserotonin O-methyltransferase
  • asmt2
  • asmt
  • CV_2261
  • Desku_0280
  • Asmt
  • ASMT
Origin
Human
5
1
1
1
1
1
Source
Escherichia coli (E. coli)
4
2
2
2
Protein Type
Recombinant
Purification tag / Conjugate
This ASMT protein is labelled with His tag.
Application
SDS-PAGE (SDS)
Options
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Purity > 90 % by SDS - PAGE
Background ASMT belongs to the methyltransferase superfamily and is involved in melatonin biosynthesis. Expressed in brain, retina and pineal gland, ASMT functions to catalyze the final reaction in the synthesis of melatonin, specifically the conversion of S-adenosyl-L-methionine and N-acetylserotonin to S-adenosyl-L-homocysteine and melatonin. Recombinant human ASMT protein, fused to His-tag at N-terminus, was expressed in E.coli.
Molecular Weight 35.3 kDa (318aa)
Comment

Synonyms: Acetylserotonin O-methyltransferase, HIOMT, HIOMTY

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/ml (determined by Bradford assay)
Buffer 20 mM Tris-HCl buffer (pH 8.0) containing 1 M Urea, 10% glycerol
Storage 4 °C
Storage Comment Avoid repeated freezing and thawing cycles.
Supplier Images
 image for Acetylserotonin O-Methyltransferase (ASMT) protein (His tag) (ABIN1098696) Acetylserotonin O-Methyltransferase (ASMT) protein (His tag)
Background publications Toma, Rossi, Sousa, Blasi, Bacchelli, Alen, Vanhala, Monaco, Järvelä, Maestrini: "Is ASMT a susceptibility gene for autism spectrum disorders? A replication study in European populations." in: Molecular psychiatry, Vol. 12, Issue 11, pp. 977-9, 2007 (PubMed).

Rodriguez, Mazuruk, Schoen, Chader: "Structural analysis of the human hydroxyindole-O-methyltransferase gene. Presence of two distinct promoters." in: The Journal of biological chemistry, Vol. 269, Issue 50, pp. 31969-77, 1995 (PubMed).

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