JAG1 Protein (AA 1-1067) (Fc Tag)
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- Target See all JAG1 Proteins
- JAG1 (Jagged 1 (JAG1))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 1-1067
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This JAG1 protein is labelled with Fc Tag.
- Application
- SDS-PAGE (SDS)
- Purpose
- Jagged-1 (human):Fc (human) (rec.)
- Cross-Reactivity
- Human
- Characteristics
- Signal peptide and extracellular domain of human Jagged-1 (HJ1, CD339) (aa 1-1067) are fused at the C-terminus to the Fc portion of human IgG1.
- Purity
- >90 % (SDS-PAGE)
- Sterility
- Sterile filtered
- Endotoxin Level
- <0.1EU/μg purified protein (LAL test).
- Biological Activity Comment
- Inhibits adipogenesis of mesenchymal stem cells (MSCs). Induces Hes-1 in 3T3L-1 cells.
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Jagged 1 (JAG1) (AA 531-620) protein (GST tag)
JAG1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Jagged 1 (JAG1) (AA 37-119) protein (GST tag)JAG1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- 0.2μm-filtered solution in PBS.
- Handling Advice
- After opening, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
- Expiry Date
- 6 months
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- Target
- JAG1 (Jagged 1 (JAG1))
- Alternative Name
- Jagged-1 (JAG1 Products)
- Background
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Protein Jagged-1, hJ1, CD339, JAG1
Jagged-1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. It is involved in cell-fate decisions during hematopoiesis. Is involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Defects in Jagged-1 are the cause of Alagille syndrome type 1 (ALGS1) and tetralogy of Fallot (TOF).
- Molecular Weight
- ~150kDa (SDS-PAGE)
- UniProt
- P78504
- Pathways
- Notch Signaling, Stem Cell Maintenance
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