TACI Protein (AA 2-118, Extracellular Domain) (Fc Tag)
(1 reference)-
- Target See all TACI (TNFRSF13B) Proteins
- TACI (TNFRSF13B) (Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- Extracellular Domain, AA 2-118
- Origin
- Human, Mouse
-
Source
- HEK-293 Cells
- Purification tag / Conjugate
- This TACI protein is labelled with Fc Tag.
- Application
- SDS-PAGE (SDS)
- Specificity
- Binds to human and mouse BAFF and APRIL.
- Cross-Reactivity
- Human, Mouse (Murine)
- Characteristics
- The extracellular domain of human TACI (aa 2-118) is fused at the C-terminus to the Fc portion of human IgG1.
- Purity
- >90 % (SDS-PAGE)
- Endotoxin Level
- <0.01EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product TNFRSF13B Protein
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Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B) (AA 2-166) protein (Fc Tag)
TNFRSF13B Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B) (AA 2-165) protein (His-DYKDDDDK-Strep II Tag)TNFRSF13B Origin: Human Host: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B) (AA 2-166) protein (Fc Tag,AVI tag,Biotin)TNFRSF13B Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B) (AA 1-160) protein (His tag)TNFRSF13B Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B) (AA 1-165) protein (His tag)Crystallography grade TNFRSF13B Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B) (AA 187-293) protein (His tag)Crystallography grade TNFRSF13B Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B) (AA 1-128) protein (His tag)Crystallography grade TNFRSF13B Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B) (AA 1-293) protein (Strep Tag)Crystallography grade TNFRSF13B Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B) (AA 1-249) protein (Strep Tag)Crystallography grade TNFRSF13B Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
-
Inhibits BAFF and APRIL activity.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Reconstitute with 50 μL sterile water.
- Concentration
- Lot specific
- Buffer
- Lyophilized. Contains PBS.
- Storage
- 4 °C,-20 °C
- Storage Comment
-
Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - Expiry Date
- 6 months
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-
: "Selective APRIL blockade delays systemic lupus erythematosus in mouse." in: PLoS ONE, Vol. 7, Issue 2, pp. e31837, (2012) (PubMed).
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: "Selective APRIL blockade delays systemic lupus erythematosus in mouse." in: PLoS ONE, Vol. 7, Issue 2, pp. e31837, (2012) (PubMed).
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- Target
- TACI (TNFRSF13B) (Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B))
- Alternative Name
- TACI (TNFRSF13B Products)
- Synonyms
- CD267 Protein, CVID Protein, CVID2 Protein, RYZN Protein, TACI Protein, TNFRSF14B Protein, TNFRSF13B Protein, 1200009E08Rik Protein, Taci Protein, TNF receptor superfamily member 13B Protein, tumor necrosis factor receptor superfamily, member 13b Protein, TNFRSF13B Protein, Tnfrsf13b Protein
- Background
- B-cell activating factor belonging to the TNF family receptor (BAFF-R), B-cell maturation antigen (BCMA), and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) play critical functions in promoting B-cell survival by engaging the ligands a proliferation-inducing ligand (APRIL) and/or BAFF. TACI is predominantly expressed on peripheral blood B cells and interacts with the B cell activating factor (BAFF) of ligands and a proliferation inducing ligand (APRIL), which are expressed by numerous cell types, including dendritic cells, macrophages and neutrophils. TNFRSF13B, the gene, which encodes TACI is mutated in nearly 10 % of patients with common variable immune deficiency (CVID), an antibody deficiency syndrome characterized by loss of memory B cells and plasma cells.
- Molecular Weight
- ~45kDa (SDS-PAGE)
- UniProt
- O14836
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