FRS2 Protein (AA 1-341) (GST tag)

Catalog No. ABIN1354441

Product Details

Target: FRS2 (Fibroblast Growth Factor Receptor Substrate 2 (FRS2))

Protein Type: Recombinant

Protein Characteristics: AA 1-341

Origin: Human

Source: Wheat germ

Purification tag / Conjugate: This FRS2 protein is labelled with GST tag.

Application: Western Blotting (WB), ELISA, Antibody Array (AA), Affinity Purification (AP)

Purpose: FRS2 (Human) Recombinant Protein (Q01)

Sequence: MGSCCSCPDK DTVPDNHRNK FKVINVDDDG NELGSGIMEL TDTELILYTR KRDSVKWHYL CLRRYGYDSN LFSFESGRRC QTGQGIFAFK CARAEELFNM SQEIMQNNSI NVVEEPVVER NNHQTELEVP RTPRTPTTPG FAAQNLPNGY PRYPSFGDAS SHPSSRHPSV GSARLPSVGE ESTHPLLVAE EQVHTYVNTT GVQEERKNRT SVHVPLEARV SNAESSTPKE EPSSIEDRDP QILLEPEGVK FVLGPTPVQK QLMEKEKLEQ LGRDQVSGSG ANNTEWDTGY DSDERRDAPS VNKLVYENIN GLSIPSASGV RRGRLTSTST SDTQNINNSA Q

Characteristics: Human FRS2 partial ORF ( AAH21562.1, 1 a.a. - 341 a.a.) recombinant protein with GST-tag at N-terminal.

Purification: in vitro wheat germ expression system

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Preparation method: in vitro, wheat germ expression system
Product Quality tested by: 12.5% SDS-PAGE Stained with Coomassie Blue.

Restrictions: For Research Use only

Handling

Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH =8.0 in the elution buffer.

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -80 °C

Storage Comment: Best use within three months from the date of receipt of this protein.

References

Krejci, Salazar, Goodridge, Kashiwada, Schibler, Jelinkova, Thompson, Wilcox: "STAT1 and STAT3 do not participate in FGF-mediated growth arrest in chondrocytes." in: Journal of cell science, Vol. 121, Issue Pt 3, pp. 272-81, (2008) (PubMed).

Krejci, Masri, Salazar, Farrington-Rock, Prats, Thompson, Wilcox: "Bisindolylmaleimide I suppresses fibroblast growth factor-mediated activation of Erk MAP kinase in chondrocytes by preventing Shp2 association with the Frs2 and Gab1 adaptor proteins." in: The Journal of biological chemistry, Vol. 282, Issue 5, pp. 2929-36, (2007) (PubMed).

Target Details

Target: FRS2 (Fibroblast Growth Factor Receptor Substrate 2 (FRS2))

Alternative Name: FRS2 (FRS2 Products)

Synonyms: frs2 Protein, wu:fd21h10 Protein, zgc:91973 Protein, FRS2A Protein, FRS2alpha Protein, SNT Protein, SNT-1 Protein, SNT1 Protein, 4732458E18 Protein, C330018A15Rik Protein, Frs2alpha Protein, fibroblast growth factor receptor substrate 2 Protein, fibroblast growth factor receptor substrate 2b Protein, FRS2 Protein, frs2b Protein, Frs2 Protein

Background: Full Gene Name: fibroblast growth factor receptor substrate 2
Synonyms: FRS2A,FRS2alpha,SNT,SNT-1,SNT1

Gene ID: 10818

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Signaling Events mediated by VEGFR1 and VEGFR2