IL1R2 Protein (C-Term, Extracellular Domain)
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- Target See all IL1R2 Proteins
- IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))
- Protein Type
- Recombinant
- Protein Characteristics
- C-Term, Extracellular Domain
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Origin
- Mouse
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Source
- HEK-293T Cells
- Specificity
- Optimized DNA sequence encoding Mouse extracellular domain of mouse IL-1 receptor type II including a C-terminal His tag was expressed in HEK293 cells.
- Characteristics
- Recombinant mouse IL-1 receptor type II (CD121b) is a protein consisting of 583 amino acid residue subunits, due to glycosylation migrates as an approximately 90 kDa protein on SDS-PAGE.
- Purity
- > 97 %, as determined by SDS-PAGE and HPLC
- Sterility
- 0.2 μm filtered
- Endotoxin Level
- Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).
- Top Product
- Discover our top product IL1R2 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS solution, pH 7.2, 5 % Trehalose.
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- -20 °C
- Storage Comment
- The lyophilized protein is stable for at least years from date of receipt at -20 °C. Upon reconstitution, this cytokine can be stored in working aliquots at - 8 °C for one month, or at -20 °C for six months, with a carrier protein without detectable loss of activity.
- Expiry Date
- 12-24 months
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- Target
- IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))
- Alternative Name
- IL1R2 (IL1R2 Products)
- Synonyms
- CD121b Protein, CDw121b Protein, IL-1R-2 Protein, IL-1RT-2 Protein, IL-1RT2 Protein, IL1R2c Protein, IL1RB Protein, Il1r-2 Protein, IL-1R2 Protein, interleukin 1 receptor type 2 Protein, interleukin 1 receptor, type II Protein, interleukin-like Protein, IL1R2 Protein, Il1r2 Protein, KK34 Protein
- Background
- IL11 is secreted by bone marrow stromal cells (fibroblasts)and is produced also by a number of mesenchymal cells. The IL11 receptor (alpha chain) utilizes gp130 as its signal transducer, which is also a component of other cytokine receptors. The alpha chain of the IL-11 receptor has been identified independently as Etl2. IL11 promotes primary and secondary immune responses in vitro and in vivo and modulates antigen-specific antibody reactions. IL11 promotes the proliferation of IL6 dependent plasmacytoma cell lines in the presence of neutralizing IL6 antibodies. IL11 also stimulates the T-cell dependent development of IgG-secreting B-cells in spleen cell cultures. IL11 inhibits the differentiation of pre-adipocytes. It induces the synthesis of some acute phase proteins by hepatocytes.
- UniProt
- P27931
- Pathways
- NF-kappaB Signaling
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