SOD2 Protein (AA 1-222) (His tag)

Catalog No. ABIN1691318

Product Details

Target: SOD2 (Superoxide Dismutase 2, Mitochondrial (SOD2))

Protein Type: Recombinant

Protein Characteristics: AA 1-222

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This SOD2 protein is labelled with His tag.

Purpose: Recombinant Human SOD2/Mn-SOD (N-6His)

Sequence: MHHHHHHDDD DKKHSLPDLP YDYGALEPHI NAQIMQLHHS KHHAAYVNNL NVTEEKYQEA LAKGDVTAQI ALQPALKFNG GGHINHSIFW TNLSPNGGGE PKGELLEAIK RDFGSFDKFK EKLTAASVGV QGSGWGWLGF NKERGHLQIA ACPNQDPLQG TTGLIPLLGI DVWEHAYYLQ YKNVRPDYLK AIWNVINWEN VTERYMACKK

Characteristics: Recombinant Human Superoxide Dismutase [Mn] Mitochondrial/SOD2 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Lys222) of Human SOD2 fused with a polyhistidine tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris,100 mM NaCl,50 % glycerol, pH 8.0.

Storage: -80 °C

Storage Comment: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Expiry Date: 6 months

Target Details

Target: SOD2 (Superoxide Dismutase 2, Mitochondrial (SOD2))

Alternative Name: SOD2 (SOD2 Products)

Synonyms: LOC100101896 Protein, MNSOD Protein, GB14346 Protein, sod2 Protein, MGC88869 Protein, Sod2 Protein, CG8905 Protein, Dmel\\CG8905 Protein, Mito SOD Protein, Mn SOD Protein, Mn-SOD Protein, Mn-SOD2 Protein, MnSOD Protein, MnSODII Protein, Mn[2+]SOD Protein, SOD Protein, SOD-2 Protein, SOD2 Protein, Sod-2 Protein, dSOD2 Protein, mitSOD2 Protein, mnSOD Protein, IPOB Protein, MVCD6 Protein, cb463 Protein, wu:fj33b01 Protein, zgc:73051 Protein, MnSOD Protein, manganese superoxide dismutase Protein, superoxide dismutase 2, mitochondrial Protein, superoxide dismutase 2 Protein, Mn superoxide dismutase Protein, Superoxide dismutase 2 (Mn) Protein, superoxide dismutase 2 L homeolog Protein, BDBG_07234 Protein, LOC100101896 Protein, MNSOD Protein, Sod2 Protein, sod2 Protein, LbMnSOD4 Protein, SOD2 Protein, LOC100282741 Protein, SOD-2 Protein, sod2.L Protein

Sub Type: Fusionprotein

Background: Superoxide Dismutase (SOD2) is a number of the iron/manganese superoxide dismutase family. SOD2 is a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. The SOD2 protein transforms toxic superoxide and a byproduct of the mitochondrial electron transport chain into hydrogen peroxide and diatomic oxygen. Genetic variation in SOD2 is associated with microvascular complications of diabetes type 6 (MVCD6), idiopathic cardiomyopathy (IDC), sporadic motor neuron disease, and cancer. SOD2 destroys superoxide anion radicals which are usually produced within the cells and which are toxic to biological systems.
Alternative Names: Superoxide Dismutase [Mn] Mitochondrial, SOD2

Molecular Weight: 23.7 kDa

UniProt: P04179

Pathways: Sensory Perception of Sound, Transition Metal Ion Homeostasis, Negative Regulation of intrinsic apoptotic Signaling