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FAH Protein (AA 2-419) (His tag)

FAH Origin: Human Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN1691329
  • Target See all FAH Proteins
    FAH (Fumarylacetoacetate Hydrolase (Fumarylacetoacetase) (FAH))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 2-419
    Origin
    • 9
    • 1
    • 1
    • 1
    Human
    Source
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Human Cells
    Purification tag / Conjugate
    This FAH protein is labelled with His tag.
    Purpose
    Recombinant Human Fumarylacetoacetase/FAH (C-6His)
    Sequence
    SFIPVAEDSD FPIHNLPYGV FSTRGDPRPR IGVAIGDQIL DLSIIKHLFT GPVLSKHQDV FNQPTLNSFM GLGQAAWKEA RVFLQNLLSV SQARLRDDTE LRKCAFISQA SATMHLPATI GDYTDFYSSR QHATNVGIMF RDKENALMPN WLHLPVGYHG RASSVVVSGT PIRRPMGQMK PDDSKPPVYG ACKLLDMELE MAFFVGPGNR LGEPIPISKA HEHIFGMVLM NDWSARDIQK WEYVPLGPFL GKSFGTTVSP WVVPMDALMP FAVPNPKQDP RPLPYLCHDE PYTFDINLSV NLKGEGMSQA ATICKSNFKY MYWTMLQQLT HHSVNGCNLR PGDLLASGTI SGPEPENFGS MLELSWKGTK PIDLGNGQTR KFLLDGDEVI ITGYCQGDGY RIGFGQCAGK VLPALLPSVD HHHHHH
    Characteristics
    Recombinant Human Fumarylacetoacetase/FAH is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Ser2-Ser419) of Human FAH fused with a polyhistidine tag at the C-terminus.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Sterility
    0.2 μm filtered
    Endotoxin Level
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
    Top Product
    Discover our top product FAH Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of PBS.
    Handling Advice
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    Storage
    4 °C/-20 °C/-80 °C
    Storage Comment
    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
    Aliquots of reconstituted samples are stable at < -20°C for 3 months.
    Expiry Date
    3 months
  • Target
    FAH (Fumarylacetoacetate Hydrolase (Fumarylacetoacetase) (FAH))
    Alternative Name
    Fumarylacetoacetase (FAH Products)
    Synonyms
    CG14993 Protein, Dmel\\CG14993 Protein, dfaa Protein, l(3)64Al Protein, l(3)SH11 Protein, PSPTO3550 Protein, fb59b12 Protein, wu:fb59b12 Protein, zgc:55316 Protein, FAA Protein, Fumarylacetoacetase Protein, FumarylAcetoacetate Hydrolase Protein, fumarylacetoacetase Protein, fumarylacetoacetate hydrolase Protein, fumarylacetoacetate hydrolase (fumarylacetoacetase) Protein, fumarylacetoacetate hydrolase (fumarylacetoacetase) L homeolog Protein, Faa Protein, fah-1 Protein, fahA Protein, hmgB Protein, Ndas_1870 Protein, Lbys_3503 Protein, Riean_0663 Protein, Ftrac_0820 Protein, Celal_3675 Protein, Celly_2655 Protein, Weevi_0208 Protein, Fluta_2435 Protein, Halhy_2019 Protein, Lacal_2931 Protein, FsymDg_1892 Protein, Fah Protein, fah Protein, fah.L Protein, FAH Protein
    Sub Type
    Fusionprotein
    Background
    Fumarylacetoacetase belongs to the FAH family. Fumarylacetoacetase is primary expressed in liver and kidney. It exists as a homodimer and catalyzes the hydrolysis of 4-fumarylacetoacetate into fumarate and acetoacetate. Defects in Fumarylacetoacetase cause tyrosinemia type 1, which is congenital metabolism defect characterized by elevated levels of tyrosine in the blood and urine, and hepatorenal manifestations. Typical features include renal tubular injury, self-mutilation, hepatic necrosis, episodic weakness, and seizures.
    Alternative Names: Fumarylacetoacetase, FAA, Beta-Diketonase, Fumarylacetoacetate Hydrolase, FAH
    Molecular Weight
    47.4 kDa
    UniProt
    P16930
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