DMP1 Protein (AA 17-513) (His tag)
DMP1
Origin: Human
Host: Human Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
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- Target See all DMP1 Proteins
- DMP1 (Dentin Matrix Acidic phosphoprotein 1 (DMP1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 17-513
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Origin
- Human
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Source
- Human Cells
- Purification tag / Conjugate
- This DMP1 protein is labelled with His tag.
- Purpose
- Recombinant Human Dentin Matrix Acidic Phosphoprotein 1/DMP-1 (C-6His)
- Sequence
- LPVTRYQNNE SEDSEEWKGH LAQAPTPPLE SSESSEGSKV SSEEQANEDP SDSTQSEEGL GSDDHQYIYR LAGGFSRSTG KGGDDKDDDE DDSGDDTFGD DDSGPGPKDR QEGGNSRLGS DEDSDDTIQA SEESAPQGQD SAQDTTSESR ELDNEDRVDS KPEGGDSTQE SESEEHWVGG GSDGESSHGD GSELDDEGMQ SDDPESIRSE RGNSRMNSAG MKSKESGENS EQANTQDSGG SQLLEHPSRK IFRKSRISEE DDRSELDDNN TMEEVKSDST ENSNSRDTGL SQPRRDSKGD SQEDSKENLS QEESQNVDGP SSESSQEANL SSQENSSESQ EEVVSESRGD NPDPTTSYVE DQEDSDSSEE DSSHTLSHSK SESREEQADS ESSESLNFSE ESPESPEDEN SSSQEGLQSH SSSAESQSEE SHSEEDDSDS QDSSRSKEDS NSTESKSSSE EDGQLKNIEI ESRKLTVDAY HNKPIGDQDD NDCQDGYVDH HHHHH
- Characteristics
- Recombinant Human Dentin Matrix Acidic Phosphoprotein 1/DMP-1 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Lys17-Tyr513) of Human DMP1 fused with a 6His tag at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Sterility
- 0.2 μm filtered
- Endotoxin Level
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
- Handling Advice
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- Storage
- 4 °C/-20 °C/-80 °C
- Storage Comment
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Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months. - Expiry Date
- 3 months
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- Target
- DMP1 (Dentin Matrix Acidic phosphoprotein 1 (DMP1))
- Alternative Name
- Dentin Matrix Acidic Phosphoprotein 1 (DMP1 Products)
- Synonyms
- ARHP Protein, ARHR Protein, DMP-1 Protein, DENTMAT Protein, AV020965 Protein, Dmp Protein, PP Protein, dentin matrix acidic phosphoprotein 1 Protein, dentin matrix protein 1 Protein, DMP1 Protein, Cyan7822_2429 Protein, dmp1 Protein, Dmp1 Protein
- Sub Type
- Fusionprotein
- Background
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Dentin Matrix Acidic Phosphoprotein 1 (DMP-1) is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. DMP-1 is expressed in teeth particularly in odontoblast, ameloblast, and cementoblast. DMP-1 is critical for proper mineralization of bone and dentin. DMP-1 may have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, the unphosphorylated form of DMP-1 acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase, DMP-1 is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite. DMP-1 mutations have also been shown to cause rickets hypophosphatemic autosomal recessive type 1 (ARHR1).
Alternative Names: Dentin Matrix Acidic Phosphoprotein 1, DMP-1, Dentin Matrix Protein 1, DMP1 - Molecular Weight
- 55 kDa
- UniProt
- Q13316
- Pathways
- p53 Signaling
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