BST2 Protein (AA 49-161) (His tag)

Catalog No. ABIN1691468

Product Details

Target: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Protein Type: Recombinant

Protein Characteristics: AA 49-161

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This BST2 protein is labelled with His tag.

Purpose: Recombinant Human Bone Marrow Stromal Antigen 2/BST2/Tetherin/CD317 (C-6His)

Sequence: NSEACRDGLR AVMECRNVTH LLQQELTEAQ KGFQDVEAQA ATCNHTVMAL MASLDAEKAQ GQKKVEELEG EITTLNHKLQ DASAEVERLR RENQVLSVRI ADKKYYPSSQ DSSVDHHHHH H

Characteristics: Recombinant Human Bone Marrow Stromal Antigen 2/BST2 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Asn49-Ser161) of Human BST2 fused with a polyhistidine tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 3 months

Target Details

Target: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Alternative Name: BST2 (BST2 Products)

Synonyms: BST2 Protein, CD317 Protein, TETHERIN Protein, 2310015I10Rik Protein, Bst-2 Protein, C87040 Protein, DAMP-1 Protein, GREG Protein, Damp1 Protein, bone marrow stromal cell antigen 2 Protein, bone marrow stromal antigen 2 Protein, BST2 Protein, LOC618737 Protein, Bst2 Protein

Sub Type: Fusionprotein

Background: Bone Marrow Stromal Antigen 2 (BST2) is a single-pass type II membrane protein that belongs to the tetherin family. BST2 is predominantly expressed in the liver, lung, heart and placenta. BST2 is involved in the sorting of secreted proteins. BST2 is a human cellular protein which inhibits retrovirus infection by preventing the diffusion of virus particles after budding from infected cells. BST2 is initially discovered as an inhibitor to HIV-1 infection in the absence of Vpu, it has also been shown to inhibit the release of other viruses such as retroviruses, filoviruses, arenaviruses, and herpes viruses. BST2 may play a role in B-cell activation in rheumatoid arthritis.
Alternative Names: Bone Marrow Stromal Antigen 2, BST-2, HM1.24 Antigen, Tetherin, CD317, BST2

Molecular Weight: 13.67 kDa

UniProt: Q10589

Pathways: Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response