TNFRSF21 Protein (AA 42-349) (Fc Tag,His tag)

Catalog No. ABIN1691790

Product Details

Target: TNFRSF21 (Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21))

Protein Type: Recombinant

Protein Characteristics: AA 42-349

Origin: Mouse

Source: Human Cells

Purification tag / Conjugate: This TNFRSF21 protein is labelled with Fc Tag,His tag.

Purpose: Recombinant Mouse Death Receptor 6/DR6/TNFRSF21/CD358 (C-Fc-6His)

Sequence: QPEQKTLSLP GTYRHVDRTT GQVLTCDKCP AGTYVSEHCT NMSLRVCSSC PAGTFTRHEN GIERCHDCSQ PCPWPMIERL PCAALTDREC ICPPGMYQSN GTCAPHTVCP VGWGVRKKGT ENEDVRCKQC ARGTFSDVPS SVMKCKAHTD CLGQNLEVVK PGTKETDNVC GMRLFFSSTN PPSSGTVTFS HPEHMESHDV PSSTYEPQGM NSTDSNSTAS VRTKVPSGIE EGTVPDNTSS TSGKEGTNRT LPNPPQVTHQ QAPHHRHILK LLPSSMEATG EKSSTAIKAP KRGHPRQNAH KHFDINEHVD DIEGRMDEPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSREEM TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGKH HHHHH

Characteristics:

Recombinant Mouse Death Receptor 6/DR6/TNFRSF21/CD358 (C-Fc-6His)

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: TNFRSF21 (Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21))

Alternative Name: Tumor Necrosis Factor Receptor Superfamily Member 21/DR6/TNFRSF21 (TNFRSF21 Products)

Synonyms: TNFRSF21 Protein, tnfrsf21 Protein, MGC146356 Protein, BM-018 Protein, CD358 Protein, DR6 Protein, AA959878 Protein, R74815 Protein, TR7 Protein, dr6 Protein, im:6795346 Protein, wu:fa55e01 Protein, wu:fb02e11 Protein, wu:fc29a09 Protein, wu:fi27h08 Protein, TNF receptor superfamily member 21 Protein, tumor necrosis factor receptor superfamily member 21 Protein, tumor necrosis factor receptor superfamily, member 21 Protein, TNFRSF21 Protein, tnfrsf21 Protein, Tnfrsf21 Protein

Background: Recombinant Mouse Tumor necrosis factor receptor superfamily member 21/DR6/TNFRSF21 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Gln42-His349) of Mouse TNFRSF21 fused with a FC-6His tag at the C-terminus.
Tumor necrosis factor receptor superfamily member 21(DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-κB and promote apoptosis and it may activate JNK and be involved in T-cell differentiation.It is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by β-secretase to release sAPP-β which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).

Molecular Weight: 64.7 kDa

UniProt: Q9EPU5

Pathways: Regulation of Lipid Metabolism by PPARalpha