SH2D1A Protein (AA 1-128) (His tag)
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- Target See all SH2D1A Proteins
- SH2D1A (SH2 Domain Containing 1A (SH2D1A))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-128
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This SH2D1A protein is labelled with His tag.
- Purpose
- Recombinant Human SH2 Domain-Containing Protein 1A/SH2D1A/SAP/DSHP (N-6His)
- Sequence
- MGSSHHHHHH SSGLVPRGSH MDAVAVYHGK ISRETGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYHGY IYTYRVSQTE TGSWSAETAP GVHKRYFRKI KNLISAFQKP DQGIVIPLQY PVEKKSSARS TQGTTGIRED PDVCLKAP
- Characteristics
- Recombinant Human SH2 Domain-Containing Protein 1A/SH2D1A is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Pro128) of Human SH2D1A fused with a 6His tag at the N-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Sterility
- 0.2 μm filtered
- Endotoxin Level
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
- Top Product
- Discover our top product SH2D1A Protein
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SH2 Domain Containing 1A (SH2D1A) (AA 1-128) protein (His tag)
SH2D1A Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
SH2 Domain Containing 1A (SH2D1A) (AA 1-128) protein (GST tag)SH2D1A Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
SH2 Domain Containing 1A (SH2D1A) (AA 1-126) protein (Strep Tag)Crystallography grade SH2D1A Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
SH2 Domain Containing 1A (SH2D1A) proteinSH2D1A Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % WB, SDS, ELISA, IP
SH2 Domain Containing 1A (SH2D1A) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)SH2D1A Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Reconstitution
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM Tris, 150 mM NaCl, 10 % Glycerol, pH 7.5.
- Handling Advice
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- Storage
- -80 °C
- Storage Comment
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Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles. - Expiry Date
- 6 months
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- Target
- SH2D1A (SH2 Domain Containing 1A (SH2D1A))
- Alternative Name
- SH2D1A (SH2D1A Products)
- Synonyms
- DSHP Protein, EBVS Protein, IMD5 Protein, LYP Protein, MTCP1 Protein, SAP Protein, SAP/SH2D1A Protein, XLP Protein, XLPD Protein, RGD1562408 Protein, Gm686 Protein, SH2D1A Protein, SH2 domain containing 1A Protein, SH2D1A Protein, Sh2d1a Protein
- Sub Type
- Fusionprotein
- Background
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SH2 Domain-Containing Protein 1A,(SH2D1A) contains one SH2 domain and a short tail and is localized in the cytoplasm. SH2D1A is expressed at a high level in the thymus and the lung, with lower expression levels in the spleen and the liver. SH2D1A acts as an inhibitor of the signaling lymphocyte activation molecule (SLAM) self-association. In addition, SH2D1A mediates interaction between FYN and SLAMF1. It is also thought to regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
Alternative Names: SH2 Domain-Containing Protein 1A, Duncan Disease SH2-Protein, Signaling Lymphocytic Activation Molecule-Associated Protein, SLAM-Associated Protein, T-Cell Signal Transduction Molecule SAP, SH2D1A, DSHP, SAP - Molecular Weight
- 16.3 kDa
- UniProt
- O60880
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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