CAMK2B Protein (AA 1-503) (His tag)

Catalog No. ABIN1692109

Product Details

Target: CAMK2B (Calcium/calmodulin-Dependent Protein Kinase II beta (CAMK2B))

Protein Type: Recombinant

Protein Characteristics: AA 1-503

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This CAMK2B protein is labelled with His tag.

Purpose: Recombinant Human CaM Kinase II Subunit β/CAMK2B (C-6His)

Sequence: MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL SARDHQKLER EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI LEAVLHCHQM GVVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY LSPEVLRKEA YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT VTPEAKNLIN QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL KGAILTTMLA TRNFSAAKSL LNKKADGVKP QTNSTKNSAA ATSPKGTLPP AALESSDSAN TTIEDEDAKA RKQEIIKTTE QLIEAVNNGD FEAYAKICDP GLTSFEPEAL GNLVEGMDFH RFYFENLLAK NSKPIHTTIL NPHVHVIGED AACIAYIRLT QYIDGQGRPR TSQSEETRVW HRRDGKWQNV HFHCSGAPVA PLQLEHHHHH H

Characteristics: Recombinant Human Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Beta/CAMK2B is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Gln503) of Human CAMK2B fused with a 6His tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 10 mM HEPES, 150 mM NaCl, pH 7.5.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: -80 °C

Storage Comment: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Expiry Date: 6 months

Target Details

Target: CAMK2B (Calcium/calmodulin-Dependent Protein Kinase II beta (CAMK2B))

Alternative Name: CAMK2B (CAMK2B Products)

Synonyms: CAM2 Protein, CAMK2 Protein, CAMKB Protein, Camk2d Protein, Ck2b Protein, camk2 Protein, camk2b Protein, cam2 Protein, camkb Protein, CAMK2B Protein, calcium/calmodulin dependent protein kinase II beta Protein, calcium/calmodulin-dependent protein kinase II, beta Protein, calcium/calmodulin-dependent protein kinase II beta Protein, calcium/calmodulin dependent protein kinase (CaM kinase) II alpha S homeolog Protein, calcium/calmodulin dependent protein kinase (CaM kinase) II beta L homeolog Protein, calcium/calmodulin-dependent protein kinase (CaM kinase) II beta Protein, CAMK2B Protein, Camk2b Protein, camk2a.S Protein, camk2b.L Protein

Sub Type: Fusionprotein

Background: Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Beta (CAMK2B) is a cytoplasmic protein that belongs to the serine/threonine protein kinase family and the Ca(2+)/calmodulin-dependent protein kinase subfamily. CAMK2B is a calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation. It is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplamic reticulum Ca2+ transport in skeletal muscle. In neurons, CAMK2B plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner.
Alternative Names: Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Beta, CaM Kinase II Subunit Beta, CaMK-II Subunit Beta, CAMK2B, CAM2, CAMK2, CAMKB

Molecular Weight: 57.4 kDa

Pathways: WNT Signaling, Interferon-gamma Pathway, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Smooth Muscle Cell Migration, Regulation of long-term Neuronal Synaptic Plasticity