UPP1 Protein (AA 1-173) (His tag)

Catalog No. ABIN1692162

Product Details

Target: UPP1 (Uridine Phosphorylase 1 (UPP1))

Protein Type: Recombinant

Protein Characteristics: AA 1-173

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This UPP1 protein is labelled with His tag.

Purpose: Recombinant Human Uridine Phosphorylase 1/UPP1 (N-6His)

Sequence: MGSSHHHHHH SSGLVPRGSH MQRKLKVTSL EPGTVVITEQ AVDTCFKAEF EQIVLGKRVI RKTDLNKKLV QELLLCSAEL SEFTTVVGNT MCTLDFYEGQ GRLDGALCSY TEKDKQAYLE AAYAAGVRNI EMESSVFAAM CSACGLQAAV VCVTLLNRLE GDQISSPRNV LSEYQQRPQR LVSYFIKKKL SKA

Characteristics: Recombinant Human Uridine Phosphorylase 1/UPP1 is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Ala173) of Human UPP1 fused with a 6His tag at the N-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris, 200 mM NaCl, 1 mM DTT, pH 8.0.

Preservative: Dithiothreitol (DTT)

Precaution of Use: This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: -80 °C

Storage Comment: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Expiry Date: 6 months

Target Details

Target: UPP1 (Uridine Phosphorylase 1 (UPP1))

Alternative Name: Uridine Phosphorylase 1/UPP1 (UPP1 Products)

Synonyms: upp1 Protein, UDRPASE Protein, UP Protein, UPASE Protein, UPP Protein, im:6911242 Protein, zgc:110755 Protein, AI325217 Protein, UPase Protein, UdRPase Protein, Up Protein, Upp Protein, uridine phosphorylase 1 Protein, uridine phosphorylase Protein, upp1 Protein, NP_RS08675 Protein, Tsp_02326 Protein, UPP1 Protein, Upp1 Protein

Sub Type: Fusionprotein

Background: Uridinephosphorylase 1 (UPP1) is a member of the family of pentosyltransferase. UPP1 catalyses the reversible phosphorolysis of uridine to uracil. The expression levels and the enzymatic activity of UPP1 are higher in human solid tumors than in adjacent normal tissues. The high level of UPP1 expression in some tumors makes it a potential prognosticfactor for some cancers, such as oral squamous cell carcinoma. UPP1 is important for the homeostatic regulation of intracellular and plasma uridine concentratios. UPP1 plays an important role in the pyrimidine salvage pathway through its catalysis of the reversible phosphorolysis of uridine to uracil.
Alternative Names: UPP1 Protein, Uridine Phosphorylase 1, UPP1

Molecular Weight: 21.3 kDa

UniProt: Q86Y75

Pathways: Ribonucleoside Biosynthetic Process