SIRPG Protein (AA 29-360) (Fc Tag)

Catalog No. ABIN1692270

Product Details

Target: SIRPG (Signal-Regulatory Protein gamma (SIRPG))

Protein Type: Recombinant

Protein Characteristics: AA 29-360

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This SIRPG protein is labelled with Fc Tag.

Purpose: Recombinant Human Signal-Regulatory Protein γ/SIRPG/CD172g (C-Fc)

Sequence: EEELQMIQPE KLLLVTVGKT ATLHCTVTSL LPVGPVLWFR GVGPGRELIY NQKEGHFPRV TTVSDLTKRN NMDFSIRISS ITPADVGTYY CVKFRKGSPE NVEFKSGPGT EMALGAKPSA PVVLGPAART TPEHTVSFTC ESHGFSPRDI TLKWFKNGNE LSDFQTNVDP TGQSVAYSIR STARVVLDPW DVRSQVICEV AHVTLQGDPL RGTANLSEAI RVPPTLEVTQ QPMRVGNQVN VTCQVRKFYP QSLQLTWSEN GNVCQRETAS TLTENKDGTY NWTSWFLVNI SDQRDDVVLT CQVKHDGQLA VSKRLALEVT VHQKDQSSDA TPVDDIEGRM DEPKSCDKTH TCPPCPAPEL LGGPSVFLFP PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE QYNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR EPQVYTLPPS REEMTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS CSVMHEALHN HYTQKSLSLS PGK

Characteristics: Recombinant Human Signal-Regulatory Protein Gamma/SIRPG is produced with our HEK293 expression system. The target protein is expressed with sequence (Glu29-Pro360) of Human SIRPG fused with a FC tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 3 months

Target Details

Target: SIRPG (Signal-Regulatory Protein gamma (SIRPG))

Alternative Name: SIRPG (SIRPG Products)

Synonyms: CD172g Protein, SIRP-B2 Protein, SIRPB2 Protein, SIRPgamma Protein, bA77C3.1 Protein, SIRPG Protein, signal regulatory protein gamma Protein, signal-regulatory protein gamma Protein, SIRPG Protein, LOC716034 Protein, LOC102138723 Protein

Sub Type: Fusionprotein

Background: Signal-Regulatory Protein Gamma (SIRPG) is a member of the signal-regulatory protein (SIRP) family and also belongs to the immunoglobulin superfamily. SIRPG is detected in the liver, and at very low levels in the brain, heart, lung, pancreas, kidney, placenta, and skeletal muscle. SIRPG is an immunoglobulin-like cell surface receptor. On binding with CD47, SIRPG mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. SIRPG as receptor-type transmembrane glycoproteins is involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes.
Alternative Names: Signal-Regulatory Protein Gamma, SIRP-Gamma, CD172 Antigen-Like Family Member B, Signal-Fegulatory Protein Beta-2, SIRP-b2, SIRP-Beta-2, CD172g, SIRPG, SIRPB2

Molecular Weight: 63.9kDa

UniProt: Q9P1W8