CGRP Protein (AA 58-141) (His tag)
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- Target See all CGRP (CALCA) Proteins
- CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 58-141
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This CGRP protein is labelled with His tag.
- Purpose
- Recombinant Human Calcitonin/CALCA (C-6His, E. coli)
- Sequence
- YVQMKASELE QEQEREGSSL DSPRSKRCGN LSTCMLGTYT QDFNKFHTFP QTAIGVGAPG KKRDMSSDLE RDHRPHVSMP QNANVEHHHH HH
- Characteristics
- Recombinant Human Calcitonin/CALCA is produced with our E. coli expression system. The target protein is expressed with sequence (Tyr58-Asn141) of Human CALCA fused with a 6His tag at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Sterility
- 0.2 μm filtered
- Endotoxin Level
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
- Top Product
- Discover our top product CALCA Protein
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Reconstitution
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl,50 % Glycerol, pH 7.4.
- Handling Advice
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- Storage
- -80 °C
- Storage Comment
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Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles. - Expiry Date
- 6 months
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- Target
- CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))
- Alternative Name
- CALCA (CALCA Products)
- Synonyms
- CALC1 Protein, CGRP Protein, CGRP-I Protein, CGRP1 Protein, CT Protein, KC Protein, CALC Protein, CALCA Protein, CALC3 Protein, ci-ct Protein, calca Protein, CA Protein, CGRP-1 Protein, Calc Protein, Calc1 Protein, Cgrp Protein, Ct Protein, Ctn Protein, calcitonin Protein, CAL6 Protein, Cal1 Protein, RATCAL6 Protein, CGRPI Protein, calc Protein, cgrp Protein, zgc:92886 Protein, calcitonin related polypeptide alpha Protein, calcitonin related polypeptide beta Protein, calcitonin-related polypeptide alpha Protein, calcitonin Protein, calcitonin/calcitonin-related polypeptide, alpha Protein, calcitonin-related polypeptide beta Protein, calcitonin gene-related peptide 2 Protein, CALCA Protein, CALCB Protein, ci-ct Protein, calca Protein, Calca Protein, LOC100008771 Protein
- Sub Type
- Fusionprotein
- Background
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Calcitonin is a secreted protein which belongs to the calcitonin family. Calcitonin is cleaved into the following two chains: Calcitonin and Katacalcin. Katacalcin is a potent plasma calcium-lowering peptide. Calcitonin is a 32-amino acid linear polypeptide hormone. Calcitonin acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH). Its importance in humans has not been as well established as its importance in other animals, as its function is usually not significant in the regulation of normal calcium homeostasis. Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
Alternative Names: Calcitonin, Katacalcin, Calcitonin Carboxyl-Terminal Peptide, CCP, PDN-21, CALCA, CALC1 - Molecular Weight
- 10.5 kDa
- UniProt
- P01258
- Pathways
- Hormone Activity, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development, Feeding Behaviour
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