Free PSA Protein
fPSA
Origin: Human
Host: Human
Native
> 90 % by SDS-PAGE
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- Target See all Free PSA (fPSA) products
- Free PSA (fPSA) (Free Prostate Specific Antigen (fPSA))
- Protein Type
- Native
- Origin
- Human
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Source
- Human
- Purification
- Purified
- Purity
- > 90 % by SDS-PAGE
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 0.01 M PBS (pH 7.4 +/- 0.2)
- Preservative
- Without preservative
- Storage
- 4 °C
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- Target
- Free PSA (fPSA) (Free Prostate Specific Antigen (fPSA))
- Alternative Name
- Free PSA (fPSA Products)
- Background
- Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is an androgen-regulated serine protease produced by both prostate epithelial cells and prostate cancer (PCa) and is the most commonly used serum marker for cancer. It is a member of the tissue kallikrein family, some of the members of which are also prostate specific. PSA is a major protein in semen, where its function is to cleave semenogelins in the seminal coagulum. PSA is secreted into prostatic ducts as an inactive 244-amino acid proenzyme (proPSA) that is activated by cleavage of seven N-terminal amino acids. Measurement of free versus total PSA can increase specificity for PCa. PSA is also widely used to monitor responses to therapy and is under investigation as a therapeutic target.
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