Plasminogen Activator, Urokinase Receptor (PLAUR) (Active) protein (His tag)

Details for Product No. ABIN1888742
Protein Name
  • PLAUR
  • u-PAR
  • Cd87
  • uPAR
  • CD87
  • U-PAR
  • UPAR
  • URKR
  • Par
  • Plaur3
  • uPAR-2
  • uPAR-3
  • plasminogen activator, urokinase receptor
  • PLAUR
  • Plaur
Origin
Human
20
5
3
1
1
Source
HEK-293 Cells
14
5
5
3
2
1
Protein Type
Recombinant
Biological Activity
Active
Purification tag / Conjugate
This PLAUR protein is labelled with His tag.
Application
SDS-PAGE (SDS)
Options
Brand CellExp™
Characteristics Molecule Information: This protein is fused with polyhistidine tag at the C-terminus, has a calculated MW of 32.1 kDa. The predicted N-terminus is Leu 23. DTT-reduced Protein migrates as 44-48 kDa due to glycosylation.
Purity ≥92 % by SDS-PAGE
Sterility 0.22 μm filtered
Endotoxin Level <1 EU/μg by LAL method
Biological Activity Comment Measured by its binding ability in a functional ELISA. Immobilized human uPAR at 5 μg/ml (100 μl/well) can bind biotinylated human UPA with a linear range of 25 - 500 ng/ml.
Protein Name
Background Urokinase plasminogen activator surface receptor (U-PAR) is also known as PLAUR, Monocyte activation antigen Mo3, CD antigen CD87. PLAUR contains three UPAR/Ly6 domains. U-PAR is expressed in neurons of the rolandic area of the brain (at protein level) and is also expressed in the brain. PLAUR / CD87 interacts with MRC2, SRPX2 and SORL1. PLAUR / UPAR act as a receptor for urokinase plasminogen activator and plays a role in localizing and promoting plasmin formation. U-PAR mediates the proteolysis-independent signal transduction activation effects of U-PA.

Alternative Names: uPAR, PLAUR, CD87, MO3
Gene ID 5329
UniProt Q03405
Pathways Inositol Metabolic Process
Application Notes Optimal working dilution should be determined by the investigator.
Comment

Human CellExp™ Recombinant Proteins provide tremendous benefits for scientists performing human cell based studies:
- They contain all the post-translational modifications (which affects the activity, function and half-life) seen in human proteins.
- They mimic native human proteins in terms of sub-unit assembly, folding, secretion and other processes.
- They show the same chemical and biological properties like stability, isoelectric point, solubility, binding affinities and biological activity.
- They are produced in serum-free medium; hence they exhibit minimal batch to batch variability and are pathogen free products.

Restrictions For Research Use only
Format Lyophilized
Reconstitution Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8 °C for up to 1 month. For extended storage, it is recommended to store at -20 °C.
Buffer Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Generally 5-8 % Mannitol or trehalose is added as a protectant before lyophilization.
Handling Advice Centrifuge the vial prior to opening.
Storage -20 °C
Storage Comment This solution can be stored at 2-8 °C for up to 1 month. For extended storage, it is recommended to store at -20 °C
Expiry Date 12 months
Supplier Images
Image no. 1 for Plasminogen Activator, Urokinase Receptor (PLAUR) (Active) protein (His tag) (ABIN1888742) Plasminogen Activator, Urokinase Receptor (PLAUR) (Active) protein (His tag)
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