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Bromodomain Containing 2 (BRD2) (AA 1-455) protein (His tag) Protein

BRD2 Origin: Human Source: Escherichia coli (E. coli) Recombinant ≥90 % by SDS-PAGE SDS
Catalog No. ABIN1888766
$295.00
Plus shipping costs $45.00 and $24.00 dry ice
100 μg
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  • Target
    BRD2
    Protein Type
    Recombinant
    Protein Characteristics
    AA 1-455
    Origin
    Human
    Source
    Escherichia coli (E. coli)
    • 6
    • 2
    • 2
    • 1
    Purification tag / Conjugate
    This BRD2 protein is labelled with His tag.
    Application
    SDS-PAGE (SDS)
    Sequence
    MGSSHHHHHH SSGLVPRGSH MGSMLQNVTP HNKLPGEGNA GLLGLGPEAA APGKRIRKPS LLYEGFESPT MASVPALQLT PANPPPPEVS NPKKPGRVTN QLQYLHKVVM KALWKHQFAW PFRQPVDAVK LGLPDYHKII KQPMDMGTIK RRLENNYYWA ASECMQDFNT MFTNCYIYNK PTDDIVLMAQ TLEKIFLQKV ASMPQEEQEL VVTIPKNSHK KGAKLAALQG SVTSAHQVPA VSSVSHTALY TPPPEIPTTV LNIPHPSVIS SPLLKSLHSA GPPLLAVTAA PPAQPLAKKK GVKRKADTTT PTPTAILAPG SPASPPGSLE PKAARLPPMR RESGRPIKPP RKDLPDSQQQ HQSSKKGKLS EQLKHCNGIL KELLSKKHAA YAWPFYKPVD ASALGLHDYH DIIKHPMDLS TVKRKMENRD YRDAQEFAAD VRLMFSNCYK YNPPDHDVVA MARKLQDVFE FRYAKMPD
    Characteristics
    Molecule Information: 52.8 kDa (478 aa, 1-455 aa + His Tag), confirmed by MALDI-TOF.
    Purity
    ≥90 % by SDS-PAGE
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    1 mg/mL in Phosphate buffer saline ( pH 7.4) containing 10 % glycerol and 1 mM DTT.
    Preservative
    Dithiothreitol (DTT)
    Precaution of Use
    This product contains dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Centrifuge the vial prior to opening.
    Storage
    -80 °C
    Expiry Date
    12 months
  • Target
    BRD2
    Synonyms
    D6S113E, FSH, FSRG1, NAT, RING3, RNF3, AW228947, D17H6S113E, Frg-1, Fsrg-1, Fsrg1, Nat, Ring3, Rnf3, mKIAA4005, brd2-a, fsh, fsrg1, nat, ring3, rnf3, brd2, fe47f02, fi85h05, wu:fe47f02, wu:fi85h05, Ring3 protein, bromodomain containing 2, bromodomain containing 2 S homeolog, bromodomain containing 2a, CHLREDRAFT_190116, CHLREDRAFT_150233, CHLREDRAFT_182576, CHLREDRAFT_188250, BRD2, Brd2, brd2.S, brd2a
    Background
    The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as "readers" of histone acetylation marks regulating the transcription of target promoters. The BET family of proteins, defined by tandem Bromodomains and an Extra Terminal domain, include BRD2, BRD3, BRD4, and BRDT. The BET proteins play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interactions. The isolated individual or tandem bromodomains of BRD2 and BRD4 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters. Small molecule inhibitors of these interactions hold promise as useful therapeutics for human disease. This protein can be used for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling.

    Alternative Names: RING3, RNF3, Bromodomain containing 4, D6S113E, FSH, FSRG1, NAT, RING3, RNF3
    Molecular Weight
    52.8 kDa
    Gene ID
    6046
    UniProt
    P25440
    Pathways
    Chromatin Binding, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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