Bromodomain Containing 2 (BRD2) (AA 1-455) protein (His tag)

Details for Product No. ABIN1888766
Protein Name
  • D6S113E
  • FSH
  • FSRG1
  • NAT
  • RING3
  • RNF3
  • AW228947
  • D17H6S113E
  • Frg-1
  • Fsrg-1
  • Fsrg1
  • Nat
  • Ring3
  • Rnf3
  • mKIAA4005
  • brd2-a
  • fsh
  • fsrg1
  • nat
  • ring3
  • rnf3
  • brd2
  • fe47f02
  • fi85h05
  • wu:fe47f02
  • wu:fi85h05
  • Ring3 protein
  • bromodomain containing 2
  • bromodomain containing 2 S homeolog
  • bromodomain containing 2a
  • CHLREDRAFT_190116
  • CHLREDRAFT_150233
  • CHLREDRAFT_182576
  • CHLREDRAFT_188250
  • BRD2
  • Brd2
  • brd2.S
  • brd2a
Protein Characteristics
AA 1-455
2
2
1
1
1
1
1
Origin
Human
9
1
1
Source
Escherichia coli (E. coli)
6
2
2
1
Protein Type
Recombinant
Purification tag / Conjugate
This BRD2 protein is labelled with His tag.
Application
SDS-PAGE (SDS)
Options
Sequence MGSSHHHHHH SSGLVPRGSH MGSMLQNVTP HNKLPGEGNA GLLGLGPEAA APGKRIRKPS LLYEGFESPT MASVPALQLT PANPPPPEVS NPKKPGRVTN QLQYLHKVVM KALWKHQFAW PFRQPVDAVK LGLPDYHKII KQPMDMGTIK RRLENNYYWA ASECMQDFNT MFTNCYIYNK PTDDIVLMAQ TLEKIFLQKV ASMPQEEQEL VVTIPKNSHK KGAKLAALQG SVTSAHQVPA VSSVSHTALY TPPPEIPTTV LNIPHPSVIS SPLLKSLHSA GPPLLAVTAA PPAQPLAKKK GVKRKADTTT PTPTAILAPG SPASPPGSLE PKAARLPPMR RESGRPIKPP RKDLPDSQQQ HQSSKKGKLS EQLKHCNGIL KELLSKKHAA YAWPFYKPVD ASALGLHDYH DIIKHPMDLS TVKRKMENRD YRDAQEFAAD VRLMFSNCYK YNPPDHDVVA MARKLQDVFE FRYAKMPD
Characteristics Molecule Information: 52.8 kDa (478 aa, 1-455 aa + His Tag), confirmed by MALDI-TOF.
Purity ≥90 % by SDS-PAGE
Protein Name
Background The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as "readers" of histone acetylation marks regulating the transcription of target promoters. The BET family of proteins, defined by tandem Bromodomains and an Extra Terminal domain, include BRD2, BRD3, BRD4, and BRDT. The BET proteins play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interactions. The isolated individual or tandem bromodomains of BRD2 and BRD4 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters. Small molecule inhibitors of these interactions hold promise as useful therapeutics for human disease. This protein can be used for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling.

Alternative Names: RING3, RNF3, Bromodomain containing 4, D6S113E, FSH, FSRG1, NAT, RING3, RNF3
Molecular Weight 52.8 kDa
Gene ID 6046
UniProt P25440
Pathways Chromatin Binding, SARS-CoV-2 Protein Interactome
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 1 mg/mL in Phosphate buffer saline ( pH 7.4) containing 10 % glycerol and 1 mM DTT.
Preservative Dithiothreitol (DTT)
Precaution of Use This product contains dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Centrifuge the vial prior to opening.
Storage -80 °C
Expiry Date 12 months
Supplier Images
Image no. 1 for Bromodomain Containing 2 (BRD2) (AA 1-455) protein (His tag) (ABIN1888766) Bromodomain Containing 2 (BRD2) (AA 1-455) protein (His tag)
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