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Interferon, alpha 10 (IFNa10) (AA 24-189) (Active) protein (Fc Tag) Protein

IFNa10 Origin: Human Source: Human Cells Recombinant > 85 % as determined by SDS-PAGE Func, SDS
Pubmed (1)
Catalog No. ABIN2002645
$285.35
Plus shipping costs $45.00
local_shipping Shipping to: United States
Delivery in 14 to 16 Business Days
  • Protein Name
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 24-189
    Origin
    Human
    Source
    Human Cells
    Purification tag / Conjugate
    This IFNA10 protein is labelled with Fc Tag.
    Application
    Functional Studies (Func), SDS-PAGE (SDS)
    Characteristics
    The recombinant human IFNA10/Fc chimera is a disulfide-linked homodimer. The reduced monomer comprises 427 amino acids with a predicted molecular mass of 48 kDa. AsrhIFNA10/Fc monomer migrates as an approximately 50 kDa band in SDS-PAGE under reducing conditions.

    Protein Structure: A DNA sequence encoding the human IFNA10 (P01566) (Cys 24-Asp 189) was fused with the Fc region of human IgG1 at the N-terminus.
    Predicted N-Term: Glu
    Purity
    > 85 % as determined by SDS-PAGE
    Endotoxin Level
    < 1.0 EU per μg of the protein as determined by the LAL method
    Biological Activity Comment
    Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitisvirus (VSV).
    The ED50 for this effect is 20-80 pg/mL.
  • Protein Name
    Background
    Synonyms: IFN-alphaC,MGC119878,MGC119879
    Molecular Weight
    48 kDa, 50 kDa
    UniProt
    P01566
    Pathways
    JAK-STAT Signaling, Hepatitis C
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
    Handling Advice
    Avoid repeated freeze-thaw cycles. It is recommended that the protein be aliquoted for optimal storage.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

    Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
    Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
    Expiry Date
    12 months
  • Xiao, Xiao, Xu, Wang, Chen, Liu, Li, Shi, Nie, Li, Wu, Liu, Ren, Guleng: "Exome sequencing identifies novel compound heterozygous IFNA4 and IFNA10 mutations as a cause of impaired function in Crohn's disease patients." in: Scientific reports, Vol. 5, pp. 10514, 2015 (PubMed).

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