Retinol Binding Protein 4, Plasma (RBP4) (AA 1-201) (Active) protein (His tag)

Details for Product No. ABIN2007447, Supplier: Log in to see
Protein Name
  • RDCCAS
  • rbp4
  • MGC54038
  • srbp
  • RBP
  • PRBP
  • RBPA
  • Rbp-4
  • fb23c12
  • rbp
  • wu:fb23c12
  • wu:fb58d04
  • wu:fb72b04
  • zgc:86911
  • retinol binding protein 4
  • retinol binding protein 4 S homeolog
  • retinol binding protein 4 A, plasma
  • retinol binding protein 4, plasma
  • retinol binding protein 4 L homeolog
  • RBP4
  • rbp4.S
  • rbp4
  • Rbp4
  • RBP4A
  • rbp4.L
Protein Characteristics
AA 1-201
24
5
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Origin
Mouse (Murine)
34
7
5
5
3
2
2
2
1
1
1
1
1
Source
Human Cells
22
10
9
6
6
5
2
1
1
Protein Type
Recombinant
Biological Activity
Active
Purification tag / Conjugate
This RBP4 protein is labelled with His tag.
Application
Functional Studies (Func), SDS-PAGE (SDS)
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Characteristics The secreted recombinant mouse RBP4 comprises 194 amino acids and has a predicted molecular mass of 22.8 kDa as estimated in SDS-PAGE under reducing conditions.

Protein Structure: A DNA sequence encoding the mouse RBP4 (NP_035385.1) (Met 1-Leu 201) was fused with a polyhistidine tag at the C-terminus.
Predicted N-Term: Glu 19
Purity > 95 % as determined by SDS-PAGE
Endotoxin Level < 1.0 EU per μg of the protein as determined by the LAL method
Biological Activity Comment Measured by its ability to bind alltrans retinoic acid. The binding of retinoic acid results in the quenching of Trp fluorescence in RBP4.
The 50% binding concentration (BC50) is >0.5 μM.
Background Synonyms: Rbp-4
Molecular Weight 22.8 kDa
NCBI Accession NP_035385
Pathways Regulatory RNA Pathways, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Production of Molecular Mediator of Immune Response
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Lyophilized
Buffer Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
Handling Advice Avoid repeated freeze-thaw cycles. It is recommended that the protein be aliquoted for optimal storage.
Storage -20 °C,-80 °C
Storage Comment Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Expiry Date 12 months
Supplier Images
 image for Retinol Binding Protein 4, Plasma (RBP4) (AA 1-201) (Active) protein (His tag) (ABIN2007447) Retinol Binding Protein 4, Plasma (RBP4) (AA 1-201) (Active) protein (His tag)
Product cited in: Zhang, Wang, Zha, Hu, Gao, Zang, Chen, Zhang, Dong: "Corona-directed nucleic acid delivery into hepatic stellate cells for liver fibrosis therapy." in: ACS nano, Vol. 9, Issue 3, pp. 2405-19, 2015 (PubMed).

Background publications Balagopal, Graham, Kahn, Altomare, Funanage, George: "Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: association with subclinical inflammation." in: The Journal of clinical endocrinology and metabolism, Vol. 92, Issue 5, pp. 1971-4, 2007 (PubMed).

Cho, Youn, Lee, Lee, Min, Kwak, Lee, Park: "Plasma retinol-binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes." in: Diabetes Care, Vol. 29, Issue 11, pp. 2457-61, 2006 (PubMed).

Zanotti, Berni: "Plasma retinol-binding protein: structure and interactions with retinol, retinoids, and transthyretin." in: Vitamins and hormones, Vol. 69, pp. 271-95, 2004 (PubMed).

Quadro, Blaner, Hamberger, Van Gelder, Vogel, Piantedosi, Gouras, Colantuoni, Gottesman: "Muscle expression of human retinol-binding protein (RBP). Suppression of the visual defect of RBP knockout mice." in: The Journal of biological chemistry, Vol. 277, Issue 33, pp. 30191-7, 2002 (PubMed).

Colantuoni, Romano, Bensi, Santoro, Costanzo, Raugei, Cortese: "Cloning and sequencing of a full length cDNA coding for human retinol-binding protein." in: Nucleic acids research, Vol. 11, Issue 22, pp. 7769-76, 1984 (PubMed).

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