Cardiotrophin 1 Protein (CTF1) (AA 2-203)
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- Target See all Cardiotrophin 1 (CTF1) Proteins
- Cardiotrophin 1 (CTF1)
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 2-203
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Origin
- Mouse
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Source
- HEK-293T Cells
- Characteristics
- The EC50 value of Mouse Cardiotrophin-1 determined by the dose-dependent proliferation of TF-1 cells was ≤ 1.25 ng/mL, corresponding to a specific activity of ≥ 0.8 x 10^6 units/mg.
- Purity
- > 95 % as analyzed by SDS-PAGE.
- Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product CTF1 Protein
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Cardiotrophin 1 (CTF1) (Active) protein
CTF1 Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE Func Active
Cardiotrophin 1 (CTF1) (AA 1-201) protein (GST tag)CTF1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Cardiotrophin 1 (CTF1) (AA 1-201) protein (His tag)Crystallography grade CTF1 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Cardiotrophin 1 (CTF1) (Transcript Variant 1) (Active) proteinCTF1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining Func, AbP, PI, STD Active
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
- Buffer
- Lyophilized after extensive dialysis against PBS.
- Storage
- -80 °C
- Storage Comment
- Lyophilized recombinant Mouse Cardiotrophin-1 remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Mouse Cardiotrophin-1 should be stable up to 1 week at 4 °C or up to 3 months at -20 °C.
- Expiry Date
- 6 months
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- Target
- Cardiotrophin 1 (CTF1)
- Alternative Name
- Cardiotrophin-1(CT-1) (CTF1 Products)
- Synonyms
- CTF1 Protein, ct1 Protein, ct-1 Protein, ctf2 Protein, CT-1 Protein, CT1 Protein, cardiotrophin 1 Protein, cardiotrophin-1 Protein, CTF1 Protein, ctf1 Protein, Ctf1 Protein, LOC100736818 Protein
- Background
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Cardiotrophin-1 (CT-1) is a member of the cytokine family which also includes IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF). CT-1 is associated with the pathophysiology of several types of heart disease including hypertension, myocardial infarction, valvular heart disease, and congestive heart failure. The protein exerts its cellular effects by interacting with the glycoprotein 130 (gp130)/leukemia inhibitory factor receptor beta (LIFR) heterodimer. CT-1 activates phosphatidylinositol 3-kinase (PI-3 kinase) in cardiac myocytes and enhances transcription factor NF-kappaB DNA -binding activities. CT-1 is highly expressed in the heart, skeletal muscle, prostate and ovary and to lower levels in lung, kidney, pancreas, thymus, testis and small intestine.Recombinant mouse Cardiotrophin-1 produced in HEK293 cells is a polypeptide chain containing 202 amino acids. A fully biologically active molecule, rmCT-1 has a molecular mass of 22-27 kDa analyzed by reducing SDS-PAGE.
Synonyms: CTF1, CT-1 - Molecular Weight
- 22-27 kDa, observed by reducing SDS-PAGE.
- UniProt
- Q60753
- Pathways
- JAK-STAT Signaling
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