CCL3L1 Protein (AA 24-93)
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- Target See all CCL3L1 Proteins
- CCL3L1 (Chemokine (C-C Motif) Ligand 3-Like 1 (CCL3L1))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 24-93
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Characteristics
- ED50< 0.4 xg/mL, measured by the FLIPR assay using CHO cells transfected with human CCR5, the receptor of human CCL3L1, corresponding to a specific activity of > 2.5x10^3 units/mg.
- Purity
- > 95 % by SDS-PAGE and HPLC analysis.
- Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product CCL3L1 Protein
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Chemokine (C-C Motif) Ligand 3-Like 1 (CCL3L1) (AA 24-93) protein (His tag)
CCL3L1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Chemokine (C-C Motif) Ligand 3-Like 1 (CCL3L1) (AA 26-93) protein (His tag)CCL3L1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % by SDS - PAGE SDS
Chemokine (C-C Motif) Ligand 3-Like 1 (CCL3L1) (AA 1-93) protein (GST tag)CCL3L1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Chemokine (C-C Motif) Ligand 3-Like 1 (CCL3L1) protein (Myc-DYKDDDDK Tag)CCL3L1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstituted in ddH2O at 100 μg/mL.
- Buffer
- Lyophilized after extensive dialysis against PBS.
- Storage
- -80 °C
- Storage Comment
- Lyophilized recombinant human LD78-beta/CCL3L1 (rhLD78-beta) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhLD78-beta remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
- Expiry Date
- 6 months
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- Target
- CCL3L1 (Chemokine (C-C Motif) Ligand 3-Like 1 (CCL3L1))
- Alternative Name
- LD78-beta/ccl3l1 (CCL3L1 Products)
- Synonyms
- 464.2 Protein, D17S1718 Protein, G0S19-2 Protein, LD78 Protein, LD78BETA Protein, MIP1AP Protein, SCYA3L Protein, SCYA3L1 Protein, C-C motif chemokine ligand 3 like 1 Protein, chemokine (C-C motif) ligand 3-like 1 Protein, CCL3L1 Protein
- Background
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LD78-beta/CCL3L1 is a proinflammatory chemokine and the isoform of Macrophage Inflammatory Protein-1 alpha (MIP-1 alpha). LD78-beta is secreted by most mature leukocytes, predominantly macrophages, and its major receptor is the G-protein coupled receptor CCR5, which is also the co-receptor used by the HIV-1 virus for cell entry. LD78-beta has superior antiviral activity and induces a variety of immune cells, particularly CD8+ T cells and immature dendritic cells. LD78-beta attracts lymphocytes and macrophages to sites of inflammation and infection, and its functions are inhibited by Interleukin-4, Interleukin-10, and Interleukin-13. Importantly, the copy number variation of LD78-beta is associated with HIV susceptibility, indicating LD78-beta's critical role in the disease.Recombinant human LD78-beta/CCL3L1 (rhLD78-beta) produced in E.coli is a single non-glycosylated polypeptide chain containing 70 amino acids. A fully biologically active molecule, rhLD78-beta has a molecular mass of 7.8 kDa analyzed by reducing SDS-PAGE.
Synonyms: SCYA3L1 - Molecular Weight
- 7.8 kDa, observed by reducing SDS-PAGE.
- UniProt
- P16619
- Pathways
- Cellular Response to Molecule of Bacterial Origin
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