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PTPN13 Protein

PTPN13 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGE and HPLC analyses. Active
Catalog No. ABIN2018353
  • Target See all PTPN13 Proteins
    PTPN13 (Protein tyrosine Phosphatase, Non-Receptor Type 13 (APO-1/CD95 (Fas)-Associated Phosphatase) (PTPN13))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Origin
    • 2
    • 1
    • 1
    Human
    Source
    • 3
    • 1
    Escherichia coli (E. coli)
    Sequence
    RLSSKSVNAQ VTDINSKGLE LRKTVTTVET QNLEGLHHDG QFCHKPCPPG ERKARDCTVN GDEPDCVPCQ EGKEYTDKAH FSSKCRRCRL CDEGHGLEVE INCTRTQNTK CRCKPNFFCN STVCEHCDPC TKCEHGIIKE CTLTSNTKCK EEGSRSN
    Characteristics
    Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit the cytotoxicity of Jurkat cells is between 10-15 μg/mL in the presence of 2 ng/mL of rHuFas Ligand.
    Purity
    > 95 % by SDS-PAGE and HPLC analyses.
    Sterility
    0.2 μm filtered
    Endotoxin Level
    < 1 EU/μg of rHusFasR/TNFRSF6 as determined by LAL method.
    Top Product
    Discover our top product PTPN13 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
    Buffer
    Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
    Handling Advice
    Avoid repeated freeze/thaw cycles.
    Storage
    4 °C/-20 °C
    Storage Comment
    This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C.
  • Target
    PTPN13 (Protein tyrosine Phosphatase, Non-Receptor Type 13 (APO-1/CD95 (Fas)-Associated Phosphatase) (PTPN13))
    Abstract
    PTPN13 Products
    Synonyms
    FAP-1 Protein, PNP1 Protein, PTP-BAS Protein, PTP-BL Protein, PTP1E Protein, PTPL1 Protein, PTPLE Protein, hPTP1E Protein, PTPN13 Protein, AI324989 Protein, Ptpri Protein, RIP Protein, Ptp-bl Protein, ptp Protein, wu:fb50g04 Protein, zgc:162319 Protein, protein tyrosine phosphatase, non-receptor type 13 Protein, tyrosine-protein phosphatase non-receptor type 13 Protein, PTPN13 Protein, LOC100540743 Protein, ptpn13 Protein, Ptpn13 Protein
    Background
    Fas and Fas Ligand (FasL) belong to the TNF superfamily and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas triggers apoptosis in Fas-bearing cells. The mechanism of apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms. These active caspases then cleave various cellular substrates leading to the eventual cell death. sFasR is capable of inhibiting FasL-induced apoptosis by acting as a decoy receptor that serves as a sink for FasL.
    Synonyms: soluble Fas receptor (sFasR), TNFRSF6, CD95, Apo I, Fas Antigen
    Molecular Weight
    17.6 kDa, a single non-glycosylated polypeptide chain containing 157 amino acids.
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