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beta-2 Microglobulin Protein (AA 21-119) (His tag)

B2M Origin: Human Host: HEK-293 Cells Recombinant >98 % as determined by SDS-PAGE.
Catalog No. ABIN2180612
  • Target See all beta-2 Microglobulin (B2M) Proteins
    beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 21-119
    Origin
    • 12
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 48
    • 11
    • 10
    • 1
    • 1
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This beta-2 Microglobulin protein is labelled with His tag.
    Sequence
    AA 21-119
    Characteristics
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 12.6 kDa. The protein migrates as 13 kDa under reducing (R) condition (SDS-PAGE).
    Purity
    >98 % as determined by SDS-PAGE.
    Sterility
    0.22 μm filtered
    Endotoxin Level
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product B2M Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handling Advice
    Please avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Target
    beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))
    Alternative Name
    beta 2-Microglobulin (B2M Products)
    Synonyms
    Ly-m11 Protein, beta2-m Protein, beta2m Protein, bwm Protein, wu:fa94c05 Protein, wu:fb10a09 Protein, b2m-W01 Protein, b2m-W03 Protein, b2m-Z01 Protein, b2m-Z02 Protein, b2m-Z03 Protein, B2M Protein, b2m Protein, B2MG Protein, wu:fb66f11 Protein, wu:fj01f08 Protein, zgc:64161 Protein, b-2-m Protein, beta-2-microglobulin Protein, beta-2 microglobulin Protein, beta-2-microglobulin S homeolog Protein, beta-2-microglobulin, like Protein, B2M Protein, B2m Protein, b2m Protein, b2m.S Protein, b2ml Protein
    Background
    β2 microglobulin is also known as Beta-2-microglobulin (B2M), is a component of MHC class I molecules which belongs to the beta-2-microglobulin family. B2M is present on all nucleated cells (excludes red blood cells). B2M associates not only with the alpha chain of MHC class I molecules, but also with class I-like molecules such as CD1 and Qa. An additional function of B2M is association with the HFE protein, together regulating the expression of hepcidin in the liver which targets the iron transporter ferroportin on the cytoplasmic membrane of enterocytes and macrophages for degradation resulting in decreased iron uptake from food and iron release from recycled red blood cells respectively. Loss of this function causes iron excess and hemochromatosis. Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP).
    Molecular Weight
    12.6 kDa
    Pathways
    TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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