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CADM1 Protein (AA 45-374) (His tag)

CADM1 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Catalog No. ABIN2180672
  • Target See all CADM1 Proteins
    CADM1 (Cell Adhesion Molecule 1 (CADM1))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 45-374
    Origin
    • 10
    • 6
    Human
    Source
    • 6
    • 4
    • 3
    • 2
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This CADM1 protein is labelled with His tag.
    Sequence
    AA 45-374
    Characteristics
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 38.5 kDa. The protein migrates as 38.5 kDa, 50 kDa and 55-85 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
    Purity
    >95 % as determined by SDS-PAGE.
    Sterility
    0.22 μm filtered
    Endotoxin Level
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product CADM1 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handling Advice
    Please avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Target
    CADM1 (Cell Adhesion Molecule 1 (CADM1))
    Alternative Name
    CADM1 (CADM1 Products)
    Synonyms
    BL2 Protein, IGSF4 Protein, IGSF4A Protein, NECL2 Protein, Necl-2 Protein, RA175 Protein, ST17 Protein, SYNCAM Protein, TSLC1 Protein, sTSLC-1 Protein, sgIGSF Protein, synCAM1 Protein, bl2 Protein, igsf4 Protein, igsf4a Protein, necl-2 Protein, necl2 Protein, ra175 Protein, sgigsf Protein, st17 Protein, stslc-1 Protein, syncam Protein, syncam1 Protein, tslc1 Protein, xnecl2 Protein, 2900073G06Rik Protein, 3100001I08Rik Protein, AI987920 Protein, Bl2 Protein, Igsf4 Protein, Igsf4a Protein, Necl2 Protein, RA175A Protein, RA175B Protein, RA175C Protein, RA175N Protein, SgIGSF Protein, SynCam Protein, Tslc1 Protein, SynCAM1 Protein, cell adhesion molecule 1 Protein, cell adhesion molecule 1 L homeolog Protein, CADM1 Protein, cadm1.L Protein, Cadm1 Protein
    Background
    Cell Adhesion Molecules (CAMs) are proteins located on the cell surface involved with the binding with other cells or with the extracellular matrix (ECM) in the process called cell adhesion. Cell adhesion molecule 1 is a single-pass type I membrane protein which belongs to the nectin family. Cell Adhesion Molecule 1 contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain, and is also known as CADM1, BL2, DKFZp686F1789, IGSF4, IGSF4A, MGC149785, MGC51880, NECL2, Necl-2, RA175, ST17, SYNCAM, TSLC1, sTSLC-1, sgIGSF, synCAM1. CADM1 mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca2+-independent manner. CADM1 acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. CADM1 may be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. CADM1 may play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
    Molecular Weight
    37.9 kDa
    NCBI Accession
    NP_055148
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Activated T Cell Proliferation
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